Objective — to study the role of melatonin in the formation of tuberculous inflammation and the prospects of its influence on increasing the effectiveness of treatment in the conditions of the COVID-19 pandemic, by conducting an analysis of information from available sources of literature on the selected topic. Materials and methods. The research was carried out for the period from December 2021 to September 2022. Access to various full-text and abstract databases was used as the main source of research. Results and discussion. A large number of studies carried out so far prove the connection between the influence of melatonin and tuberculosis inflammation, since tuberculosis infection can be associated with seasonal changes in the immune system, and these processes are correlated and accompanied by fluctuations in the level of melatonin. Th1-type specific cellular immunity is responsible for protective immunity in tuberculosis, while the Th2-type response underlies the progressive nature of inflammation. T-lymphocytes and macrophages have been shown to have receptors for melatonin, and they are also target cells for its immunomodulatory function. Melatonin has been shown to regulate gene expression of several immu­nomodulatory cytokines, including TNF-α, transforming growth factor-β, and macrophage stem cell factor.Thus, the conducted narrowly differentiated analysis based on available literature sources allows us to predict that melatonin can stimulate the Th1 immune response in TB and may have an immunoprotective effect on the Th1-type subtype of the delayed-type immune response during the acute phase of mycobac­terial inflammation. Conclusions. The analysis of the tuberculosis situation in Bukovina indicates a tendency towards an increase in the incidence rate in 2021 compared to 2020. The same dynamics are maintained in the first half of 2022. At the same time, no significant changes in the mortality rate were found. The above analysis of the main indicators of epidemiology indicates the sufficient importance of the problem of tuberculosis for the coming years, and therefore, the search for methods of increasing the effectiveness of the treatment of this pathology, especially under the conditions of multiple and extended drug resistance, is an important task of modern phthisiology. The analysis of the available data base accumulated to date on the role of melatonin in the pathophysiology of the formation of an inflammatory reaction in the lungs and its influence on the clinical course and effectiveness of anti-tuberculosis therapy is a promising scientific direction of research. The appointment of melatonin along with traditional methods of treatment of tuberculosis can have a positive effect on increasing the effectiveness of anti-tuberculosis therapy in patients with the pulmonary form of tuberculosis.

During postgraduate studies, future PhDs must master a wide range of teaching and research skills that meet global and European academic standards. In particular, candidates for the degree of Doctor of Philosophy must acquire theoretical knowledge that is sufficient to produce new ideas, solve complex problems in the field of professional and/or research and innovation, acquire universal research skills, including oral and written presentation of their own scientific results, application of modern information technologies in scientific activity, organization and carrying out of educational employments, management of scientific projects and/or introduction of offers concerning financing of scientific researches, registration of the intellectual property rights. Objective — to summarize information about the relevance of the discipline «Presentation and imple­mentation of the results of the own scientific research» and highlight practical approaches to its teaching. Materials and methods. Analysis and generalization of information on current documents governing the educational process for applicants for the degree of «Doctor of Philosophy» in medical specialties, and literature sources on the presentation and implementation of dissertation research. Results and discussion. The discipline «Presentation and implementation of the results of the own scientific research» is an important component of the preparation of graduates of the degree of Doctor of Philosophy in the field of knowledge 22 «Health». As part of the study of this discipline, students learn the concept of innovation process and innovation of the scientist, get acquainted with the basics of protection of the results of their own research and modern aspects of patent information search technologies, gain skills in presenting the results of the own research using various forms of new information technologies and implementation in the practice of health care and educational process of the results of the own research. Conclusions. Assimilation of theoretical material and practice of the practical part of the program of the discipline «Presentation and implementation of results of the own scientific research» provides acquisition by postgraduate students of corresponding integral, general and special competences and formation of integrative final program results of training necessary for further professional activity of the future doctor of philosophy.

BACKGROUND. The main task of modern phthysiology is a comprehensive search for ways to optimize the etiotropic and the pathogenetic treatment of tuberculosis (TB). The search for improved treatment in addition to etiotropic antimicrobial therapy lies in the plane of improving pathogenetic therapy. Analysis of the available scientific sources suggests that the efficacy of TB treatment can be improved by adding vitamin D to the pathogenetic treatment, as vitamin D metabolites support the innate immune response to Mycobacterium tuberculosis. OBJECTIVE. To determine the role of vitamin D in the immunopathogenesis of the inflammatory response in pulmonary TB and to assess the prospects of its impact on improving the effectiveness of treatment by analyzing information from available scientific sources on this topic. MATERIALS AND METHODS. The study was performed for the period December 2020 – August 2021. The search was conducted by Keywords: pulmonary tuberculosis, vitamin D, mechanism of action, pathogenesis, treatment. Access to various full-text and abstract databases was used as the main source of research. RESULTS AND DISCUSSION. A large number of studies conducted so far prove the link between vitamin D deficiency and the occurrence of pulmonary TB. Vitamin D receptors have been found to be present on various surfaces of immune cells, including T and B cells, indicating that they need vitamin D to perform cellular functions. Vitamin D has been shown to increase the phagocytic activity of macrophages, and that monocytes incubated with cholecalciferol (vitamin D3) metabolites induce anti-TB activity. A number of studies have shown that vitamin D increases the body’s production of the antimicrobial/antimycobacterial peptide LL-37, a member of the cathelicidin petelide family. Therefore, the narrowly analyzed analysis according to the literature suggests that in the conditions of full vitamin D status of the human body the course of TB will be favorable, and in case of vitamin D deficiency – which is primarily associated with genetic polymorphisms, the course of TB may be unfavorable. CONCLUSIONS. Vitamin D functionates as one of the activators of macrophages and plays a role in the immune defense of the human body against mycobacterial TB. The inclusion of vitamin D in the program of complex treatment of TB infection is promising, as it enhances the production of antimicrobial/antimycobacterial peptide LL-37. It can be used as one of the components of TB prevention in children.