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ПоЛИморФНЫЕ варИаНТЫ ГЕНа tlr6 У вЗроСЛЫХ ПаЦИЕНТов С БроНХИаЛЬНой аСТмой Л. ю. Барычева, Л. в. Шушанова, а. в. ягода, м. в. Голубева, м. м. минасян Ставропольский государственный медицинский университет, российская Федерация Immunogenetic studies were performed in 65 people with allergic bronchial asthma (BA) and 35 with non-allergic BA. This study established that the molecular genetic markers for an increased risk of allergic BA are allele TLR6 745C and TLR6 C745T. This association of polymorphic markers of the TLR6 gene is confirmed only for allergic BA. An increased risk of allergic asthma was found in carriers of the common allele TLR6 745C and those with the heterozygous genotype C745T.

БИоЛоГИЧЕСКая ТЕраПИя рЕвмаТоИдНоГо арТрИТа: рЕаЛЬНа ЛИ ПрЕдИКЦИя ЭФФЕКТИвНоСТИ? П. в. Корой, в. д. Саритхала, а. в. ягода Ставропольский государственный медицинский университет, российская Федерация Relationship of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), plateletendothelial cell adhesion molecule-1 (PECAM-1), E-, P-and L-selectins blood levels with results of three-monthly combination treatment by biological agents and methotrexate was studied in 35 patients with rheumatoid arthritis (29 women, 6 men) at age from 40 to 66 with previous noneffective methotrexate treatment. Tocilizumab was applied in 20 patients, in 15 cases etanercept was used. The moderate effect of treatment was observed in 74.3 % of cases, remission or low activity of rheumatoid arthritis were reached in 22.9 % of patients, 9 patients were non-responders. Increase of blood concentration of all immunoglobulins superfamily molecules and of P-selectin was observed in rheumatoid arthritis. After 3 months of therapy decrease in VCAM-1, PECAM-1 blood levels and normalization of ICAM-1, P-selectin values were observed, especially in cases of effective treatment, in non-responders there was reduction only of ICAM-1 levels. The favorable response to treatment was associated with high initial levels of ICAM-1, РЕСАМ-1 and low levels of P-selectin in blood that opens new possibilities of use of adhesion molecules in prediction of successful therapy of RA.