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A magnetic field sensor based on a tilted fiber Bragg grating (TFBG) coated with magnetic fluid is proposed and demonstrated experimentally. The sensing element is made by injecting the magnetic fluid into a capillary tube which contains a TFBG. The resonant wavelengths of the cladding modes of TFBG shift by varying the magnetic field which is perpendicular to the axis of TFBG. The results indicate that the resonant wavelength shifts of the cladding modes show a nonlinear dependence on the magnetic field. As the magnetic field increases to 32 mT, the largest resonant wavelength shift reaches to 106 pm. Moreover, this sensor shows good repeatability when it is used for magnetic field sensing.

Cylindrical-vector beams (CVBs) with axial symmetry in polarization and field intensity are gathering increasing attention from fundamental research to practical applications. However, a majority of the CVBs are generated by modulating light beams in free space, and the temporal durations are far away from the ultrafast regime. Here, an ultrafast all-fiber based CVB laser is demonstrated via intermodal coupling in two mode fibers. In the temporal domain, chirp-free pulses are formed with combined actions of the ultrafast saturable absorption, self-phase modulation, and anomalous dispersion. In the spatial domain, the lateral offset splicing technique and a two mode fiber Bragg grating are adopted to excite and extract CVBs, respectively. The ultrafast CVB has an annular profile with a duration of 6.87 ps and a fundamental repetition rate of 13.16 MHz, and the output polarization status is switchable between radially and azimuthally polarized states. This all-fiber-based ultrafast CVB laser is a simple, low-cost source for diversified applications of nanoparticle manipulation, high-resolution imaging, material processing, spatiotemporal nonlinear optics, etc.

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African swine fever (ASF) is a devastating infectious disease caused by African swine fever virus (ASFV). The ASFV genome encodes multiple structural and non-structural proteins that contribute to evasion of host immunity. In this study, we determined that the viral non-structural protein MGF360-14L inhibits interferon-β (IFN-β) promoter activity induced by cGAS-STING signaling. MGF360-14L was also found to downregulate expression of the IRF3 protein and promote its degradation through ubiquitin-meditated proteolysis. Moreover, MGF360-14L was shown to interact with and destabilize IRF3 by facilitating E3 ligase TRIM21-mediated K63-linked ubiquitination of IRF3. Overall, our study revealed that MGF360-14L promotes degradation of IRF3 through TRIM21, thereby inhibiting type I interferon production. These findings provide new insights into the mechanisms underlying ASFV immune evasion.