Purpose: Atherosclerosis is among the major factors in ischemic stroke. It has been set forth that serum levels decline of adiponectin, which is produced from adipose tissue and downgrades atherosclerosis, in the presence of atherosclerosis risk factors such as obesity, HT, DM, and hyperlipidaemia. In this study, we aimed at examining the relation between levels of the serum adiponectin and consciousness in patients with ischemic stroke. Method: 17 patients with acute ischemic stroke, who applied within the 24 hours after stroke and who are above the age of 45, were involved in the study and compared to the 22 healthy control group of similar age. The levels of adiponectin were measured in the serum samples of the patients taken within the first 24-48th hours of the patients and their levels of consciousness were evaluated with Glasgow coma score. Results: While adiponectin levels are 17.16 ± 0.9 microg/mL in healthy cases, 8.80 ± 0.7 microg/mL has been found in ischemic stroke group and the difference between them was statistically significant (p<0.001). No statistically significant relation between consciousness and adiponectin levels of the patients with stroke were found (p<0.1). Conclusion: The levels of adiponectin significantly declines in the presence of ischemic stroke. Efforts aimed at raising low levels of adiponectin can be one of the treatment objectives of ischemic stroke.