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As part of the design process of a chiller plant, one of the final stages is the energy testing of the system in relation to future operating conditions. Recent studies have suggested establishing robust solutions, but a conservative approach still prevails at this stage. However, the results of some recent studies suggest the application of a new co-design (control–design) approach. The present research involves a comparative analysis between the use of conventional staging and the co-design approach in the design phase of a chiller plant. This paper analyzes the energy consumption estimations of six different chiller plant combinations for a Cuban hotel. For the conservative approach using on/off traditional staging, the results suggest that the best option would be the adoption of a chiller plant featuring a symmetrical configuration. However, the outcomes related to the co-design approach suggest that the best option would be an asymmetrical configuration. The energy savings results were equal to 24.8% and the resulting coefficient of performance (COP) was 59.7% greater than that of the symmetrical configuration. This research lays firm foundations for the correct choice and design of a suitable chiller plant configuration for a selected hotel, allowing for significant energy savings in the tourism sector.

An appropriate design of a chiller plant is crucial to guarantee highly performing solutions. However, several design variables, such as type of systems, total cooling capacity, and hydraulic arrangement, need to be considered. On the one hand, at present, different technical criteria for selecting the most suitable design variables are available. Studies that corroborate the influence of the design variables over the operational variables are missing. In order to fill this knowledge gap, this work proposes a statistical analysis of design variables in chiller plants operating in medium- and large-scale applications and evaluates their influence on energy consumption and life cycle cost (LCC) under the same thermal demand conditions. A case study involving 138 chiller plant combinations featuring different arrangements and a Cuban hotel was selected. The results suggested that the total chiller design and cooling capacity distribution among chillers have a significant influence on the energy consumption of the chiller plant with a Spearman’s Rho and Kendall Tau (τ) correlation index value of −0.625 and 0.559, respectively. However, with LCC, only the cooling capacity distribution among the chillers had a certain influence with a Kendall Tau correlation index value of 0.289. As for the considered total cooling capacity, the applied statistical test showed that this design variable does not have any influence on performing the chiller plant.