Background and purpose There is a lack of a reliable outcome prediction model for patients evaluating the feasibility of postoperative adjuvant transarterial chemoembolization (PA-TACE) therapy. Our goal was to develop an easy-to-use tool specifically for these patients. Methods From January 2013 to June 2017, patients with liver cancer from the Liver Center of the First Affiliated Hospital of Chongqing Medical University received postoperative adjuvant Transarterial chemoembolization (TACE) therapy after liver cancer resection. A Cox’s proportional hazards model was established for these patients, followed by internal validation (enhanced bootstrap resampling technique) to further evaluate the predictive performance and discriminance, and compare with other predictive models. The prognostic factors considered included tumour number, maximum tumor diameter, Edmondson-Steiner (ES) grade, Microvascular invasion (MVI) grade, Ki67, age, sex, hepatitis B surface antigen, cirrhosis, Alpha-fetoprotein(AFP), Albumin-bilirubin (ALBI) grade, Child-pugh grade, body mass inex (BMI), Neutrophil-lymphocyte ratio (NLR), Platelet-to-lymphocyte ratio (PLR). Results The end point of the study was overall survival. The median overall survival was 31.8 (95%CI: 30.0-33.6 ) months, with 1-year, 2-year and 3-year survival rates being 96.3%, 84.0% and 75.3%, respectively. Tumour number, MVI grade, and BMI was incorporated into the model, which had good differentiation and accuracy. Internal validation (enhanced bootstrap ) suggested that Harrell’s C statistic is 0.72 (a measure of discrimination, with higher values indicating better discrimination). The model consistently outperforms other currently available models. Conclusions This model may be an easy-to-use tool for screening patients suitable for PA-TACE treatment and guiding the selection of clinical protocols. But further research and external validation are required.
Background The higher professional identity of general practitioners (GPs) helps to promote the establishment of hierarchical diagnosis and treatment in China. However, previous studies focus on the investigation of specialists. As the main provider of residents’ health services, GPs are the basis of primary health care services in China. This study aims to investigate the professional identity of GPs and its influencing factors. Methods A cross-sectional online questionnaire survey was conducted from December 2021 to January 2022, and subjects were selected by two-stage stratified random sampling. A self-administered questionnaire was used to collect data from 2,200 GPs (99.1% response rate) in Chongqing, a municipality in western China. Practicing identity was measured by the Practicing Identity Scale, psychological capital was measured by the Psychological Capital Questionnaire (PCQ-24), and patients were measured by the Perceptual Patient Slowness Questionnaire. Through the construction of a multiple linear regression model to analyze correlation, the related factors of GPs’ professional identity are discussed. Results The total score of professional identity of GPs was 65, with an average score of 53.59 (SD = 6.42). The scores of self-efficacy, hope, optimism, and resilience in psychological capital were 26.87 ± 5.70, 26.47 ± 5.74, 26.97 ± 5.55, and 26.86 ± 5.59, respectively. The score of perceived patients was 34.19 ± 7.59. Average monthly income, management responsibility, work tenure, self-efficacy, hope, resilience, and patient’s contempt are related to practice identity (P < 0.05). Conclusions GPs in Chongqing, a municipality directly under the central government in western China have high professional identity and strong psychology.
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