A t least ≥30% of strokes in China are intracerebral hemorrhages (ICH) when compared with ≈15% in Western countries, with a noticeable south-north gradient. [1][2][3][4] In absolute terms, this equates to large numbers of cases in China, and interventions to reduce the effects of ICH are important to determine. This is because ICH is generally more severe than ischemic stroke 5 and is associated with poorer functional outcome and higher case-fatality. 6 Evidence suggests that very early physical rehabilitation (VER) of stroke survivors may result in better motor recovery, reduced mental, functional and neurological disability, and improved quality of life. 7-11However, previous studies have included only small proportions of people with ICH, 8,10 and further research in large phase III studies for all stroke subtypes is still needed. 12Patients who have experienced ICH may differ to those with ischemic stroke in regards to risk factors, mechanisms of Background and Purpose-Mechanisms, acute management, and outcomes for patients who experience intracerebral hemorrhage may differ from patients with ischemic stroke. Studies of very early rehabilitation have been mainly undertaken in patients with ischemic stroke, and it is unknown if benefits apply to those with intracerebral hemorrhage. We hypothesized that early rehabilitation, within 48 hours of stroke, would improve survival and functional outcomes in patients with intracerebral hemorrhage. Methods-This was a multicenter, randomized controlled study, with blinded assessment of outcome at 3 and 6 months.Eligible patients were randomized to receive standard care or standard care plus early rehabilitation. Primary outcome includes survival. Secondary outcomes includes health-related quality of life using the 36-item Short Form Questionnaire, function measured with the modified Barthel Index, and anxiety measured with the Zung Self-Rated Anxiety Scale. Results-Two hundred forty-three of 326 patients were randomized (mean age, 59 years; 56% men). At 6 months, patients receiving standard care were more likely to have died (adjusted hazard ratio,

Medullary thyroid carcinoma (MTC) is a neuroendocrine cancer derived from parafollicular C cells in the thyroid gland. It has great interest as a research focus because of its unusual genetic, clinical, and prognostic characteristics. However, the pathogenesis in MTC is not completely clear. We investigated the role of miR-9-3p and bladder cancer-associated protein (BLCAP) in MTC TT cells. First, miR-9-3p expression was upregulated in human MTC tissues and TT cells and compared to the control by RT-PCR. Flow cytometric analysis indicated that the cell cycle progression in TT cells was significantly inhibited by the miR-9-3p inhibitor but was increased by the miR-9-3p mimic. On the contrary, the apoptosis of TT cells was significantly increased by the miR-9-3p inhibitor and suppressed by the miR-9-3p mimic. A similar change pattern was observed in the expression of apoptosis-regulated protein caspase 3 induced by the miR-9-3p mimic or inhibitor in TT cells. We then identified that BLCAP is a target of miR-9-3p by bioinformatic prediction and luciferase reporter assay. The expression of BLCAP was also significantly downregulated by the miR-9-3p mimic while being upregulated by the miR-9-3p inhibitor in TT cells. Furthermore, we confirmed that the inhibited apoptosis of TT cells induced by the miR-9-3p mimic was enhanced by BLCAP overexpression. The levels of apoptosis were strongly decreased by BLCAP silencing in TT cells, which were not further influenced by the miR-9-3p inhibitor. In summary, upregulated miR-9-3p has a positive role in human MTC progression by regulating the growth and apoptosis of cancer cells via targeting BLCAP. This might represent a possible diagnosis or therapeutic target for MTC.

The largest mesh size ξ of a multicyclic branched polymer network results in special microrheological behavior and unique viscosity modification applications in solution.

The ring-forming behavior of polymers with odd-numbered-arm in high dilute solutions has been studied using tri-arm polystyrene (PSt3) as model through combining atom transfer radical polymerization (ATRP) and atom transfer...