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In this work, three plasticizers with different molecular structures were used to plasticize poly(vinyl chloride) (PVC), and the influence of different plasticizers on the flexural fatigue properties of soft PVC was investigated. The plasticizer with the best plasticizing effect was selected, and five gradient dosages were set to study the optimal ratio of plasticizer and PVC. It was found that the glass transition temperature of samples with two phthalate plasticizers (DPHP, 1012P) was lower than that with trimellitate plasticizer (TM‐8). It has excellent low‐temperature mechanical properties and great flexural fatigue resistance. From the comparison of different plasticizer gradient formulations, the glass transition temperature, PVC plastisol viscosity, and melt strength decreased gradually with the increase of plasticizers. When PVC and plasticizer were 1:1 (PVC50P50), the plasticizing effect and the low‐temperature toughness of the sample were the best. The breaking energy (W) and fatigue cycles of Bally Flex at −20°C were 5173 J m−3 and 141 000, respectively. It was concluded that W and Bally Flex fatigue life have a good positive correlation n. Thus, tensile test can be simply used to predict Bally Flex fatigue life of samples.

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