Latar Belakang: Hipertensi di Indonesia menempati urutan keenam untuk penyakit tidak menular dengan angka kejadian sebesar 25,8% pada usia ≥18 tahun. Di Kota Serang sendiri dari hasil pengukuran darah dari 38.409 yang diukur tekanan darahnya didapatkan 10.845 yang menderita hipertensi atau sebesar 28,2% dengan jumlah persentase lebih tinggi pada perempuan yaitu sebanyak 7.659 atau sebesar 32.8%. Pedoman penatalaksanaan hipertensi menurut Joint National Committee (JNC) 8 mempertimbangkan usia, ras, dan komplikasi untuk mencapai target tekanan darah. Metode: Penelitian ini adalah penelitian analitik observasional dengan desain potong lintang. Populasi penelitian ini adalah pasien Hypertensive Heart Disease (HHD) di RSUD Drajat Prawiranegara Serang yang memenuhi kriteria, yaitu pasien HHD dengan obat anti hipertensi kombinasi Angiotensin Reseptor Blocker (ARB)+Beta Blocker (BB) dan Calsium Channel Blocker (CCB)+Beta Blocker (BB) sebanyak 35 pasien. Tehnik sampling yang digunakan adalah purposive sampling. Hasil: Uji statistik Chi-square didapatkan nilai p = 0.830 pada hubungan antara pengunaan obat antihipertensi dengan penurunan tekanan darah pada pasien Hypertensive Heart Disease.Kesimpulan: Tidak terdapat perbedaan efektivitas penurunan tekanan darah antara kombinasi obat antihipertensi golongan ARB+BB dan CCB+BB pada pasien HHD.

Background: Moringa oleifera fruit extract contains beneficial chemical compounds. This study was conducted to observed the power of antioxidant against liver injury by 2-Nitropropane induction in an obese male mice model. Methods: This research was in vivo laboratory experimental study with a post-test control design group only. The population was obese male mice models, Swiss strain, aged 6–8 weeks, weighing between 60–80 gr. The research sample was determined by Federer's formula for a complete randomized design experimental test, group N (control), O1 (induced by 2-Nitropropane intraperitoneal (i.p) once), O2 (induced by 2-Nitropropane i.p twice), P1 (induced by 2-Nitropropane i.p. once and gavage with M. oleifera fruit extract 500mg/kg bodyweight (BW) once a day), P2 (induced by 2-Nitropropane i.p. twice and gavage of M. oleifera fruit extract 500mg/kg BW once a day), and P3 (induced by 2-Nitropropane i.p. twice and gavage of vitamin C 500mg/kg BW once a day). Antioxidant potential parameters were measured by levels of malondialdehide (MDA), glutation (GSH), 8-hydroxy-2'-deoxyguanosine (8-OHdG), catalase activity, manganese superoxide dismutase (MnSOD), serum glutamic pyruvic transaminase (SGPT), serum glutamic oxaloacetic transaminase (SGOT). This research was held at the Biochemistry laboratory of Medicine Faculty, UPN Veteran Jakarta in May–September 2020. Analysis was carried out using SPSS version 20.0. The parameters were tested using ANOVA. Results: MDA levels decreased, GSH increased, 8-OHdG decreased, catalase activity increased, MnSOD activity increased and SGOT, SGPT levels decreased. M. oleifera fruit extract was statistically proven to be a candidate for potential antioxidant against liver injury of 2-Nitropropane induction in obese male mice model.  Conclusions: M. oleifera fruit extract was statistically evident as an antioxidant substance that reduces oxidative stress in acute liver injury caused by 2-Nitropropane induction.