Please be advised that this information was generated on 2018-05-11 and may be subject to change. letters to natureSequences (MIPS) databases were reconciled. Ty elements and dubious open reading frames (ORFs) were excluded. The data set (5,790 proteins) and search results can be viewed at the URL http://acer.gen.tcd.ie/~khwolfe/yeast. Repetitive regions within proteins were masked using the SEG filter in BLAST.Statistical analysis. Chi-square tests (data not shown) indicate that duplicated genes in yeast are distributed in a highly non-random manner with regard to both the order in which homologous genes occur on pairs of chromosomes and the transcriptional orientations of those genes. A simultaneous origin of duplicate regions, as opposed to 55 independent duplications, is supported by a chi-square test on block orientations and by the lack of triplicated regions. The Poisson expectation if blocks were duplicated sequentially is for approximately 40 duplicated blocks, and 7 blocks that are replicated more than once (mainly triplicated). There is only one possible candidate for a triplicated region: the genes YDR474Q YDR492W10 inferred substitutions on branch A. One gene pair, ORC1/SÏR3, was omitted because one of the yeast genes appeared more similar to its human homologue than to its duplicate.

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