Patients with long-term effects of coronavirus disease, the so-called “long-term COVID-19 syndrome” (long-COVID-19) after SARS-CoV-2 infection, have a postponed recovery lasting from 4 weeks and up to six months, spread worldwide. Physiological predictors based on human blood biomarkers and host-virus responses to SARS-CoV-2 are still unknown. There is growing evidence about the impact of micronutrients on improving lymphocyte proliferation and their essential roles for a functioning human immune system and regulating metabolic health. This paper aims to review information about micronutrients in patients with SARS-CoV-2 infection that determines long-COVID-19 outcomes and highlight the importance of diagnostics in predictors of long-COVID-19. We reviewed articles returned from searches on PubMed/SCOPUS/Web of Science/ EMBASE databases using a combination of terms “long COVID-19”, “long-term effects of COVID-19”, “post-COVID-19 symptoms”, “COVID-19 associated stress”, “micronutrients”. Evidence indicates the relationship between lymphocyte proliferation improving micronutrient level and long-COVID-19 induction. Zinc, selenium, iron, manganese have an immunomodulatory function in innate and adaptive immune responses to viral infection. Anti-inflammatory functions of Vits A and B groups include the regulation of lymphocyte proliferation and metabolic health. Further research using sampling and artificial intelligence-assisted algorithms could assist in the recognition of the correlation of micronutrients and long-COVID-19 clinical outcomes

Given the rapid progress of modern science, integrative physiology holds a key place in medical education, as it studies patterns of human body functioning in terms of individual characteristics, epigenetic factors and endogenous effects on cellular mechanisms. Drawing on five years of experience in teaching physiology at Danylo Halytsky Lviv National Medical University, we highlight the importance of implementing applied integrative physiology in the training of future doctors. We present interpretation of physiological phenomena, adaptive mechanisms and compensation resources in the human body. The introduction of methods for assessing human functions in real time based on high-precision registration of individual functional characteristics and adaptive physiological mechanisms with high diagnostic value, allows future doctors to develop clinical competencies in modern principles of medical science, personalized medicine, and preventive healthcare strategies