The current study aimed to investigate the relationship of cognitive emotion regulation and meaning in life with health anxiety in nurses working in emergency department. Materials and Methods: It was a descriptive research in the form of correlation and prediction. The sample included 100 emergency nurses in Sari City, Iran selected by randomized method of sampling. The participants completed items of the Cognitive Emotion Regulation Questionnaire (CERQ), the Meaning in Life Questionnaire (MLQ) and health anxiety questionnaire. The research data were analyzed by descriptive statistics indices, Pearson correlation analysis, Partition coefficient, and multivariate regression, using SPSS. Results: The results suggested a significant relationship between cognitive emotion regulation and health anxiety, especially in the subscale of rumination in terms of negative cognitive emotion regulation. Also, there was a significant relationship between meaning in life and health anxiety. Conclusion: Generally, findings of this research can be useful in future studies regarding the effect of meaning in life and cognitive emotion regulation on health anxiety.