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Silver nanoparticles vary in size from 1 to 100 nm. These have unique properties that assists in molecular diagnostics, therapies, and devices used in many medical procedures. The most popular methods for making silver nanoparticles are physical and chemical approaches. Chemical and physical methods are troublesome because synthesis is expensive. The biological approach is a feasible alternative one. The major biological processes involved are bacteria, fungi, and plant extracts. Silver nanoparticles are mainly used in diagnostic and therapeutic applications in medicine. Their medical uses rely on the antimicrobial property, while the anti-inflammatory property has its own range of applications. Silver nanoparticles are used in a number of medical therapies and instruments, as well as in a variety of biological sciences. This article focuses on chemical and biological techniques for synthesizing AgNPs, which will subsequently be utilized to coat socks materials, testing antimicrobial activity and comparing the ability of these coated fabrics to minimize infections.

Breast cancer is the most frequent cancer among women around the world. Various studies have looked into the causes of that cancer in order to find a technique to diagnose it early and treat it effectively. The current study investigated the relationship between the decrease of an antioxidant enzyme among breast cancer patients and the effect of chemotherapy on it. This study investigated the relationship between the reduction of antioxidant enzymes and the effect of chemotherapy in breast cancer patients. The survey was conducted on 70 histopathologically diagnosed breast cancer patients (all women) from the Babylon Mirjan Medical City Oncology Centre, with 30 apparently healthy women serving as controls. The current study found differences in some biochemical markers between controls and cases with breast cancer. The Superoxide dismutase (SOD) activity in the control was (64.4023.76) U/ml, while its activity in the case was significantly decreased to reach (9.516.59) U/ml in the first group (1–5 doses) and (9.254.62) U/ml in the second group (6–10), and the GSH concentration in the control was (17.579.09), whereas its activity in the case was significantly reduced to reach (2.070.88) umol/ml in the first group (1–5), (2.341.65).

<abstract> <p>Oxidative stress factors are among the most common carcinogens, Superoxide dismutase enzyme-2 (SOD2) is an endogenous antioxidant involved in the scavenging of superoxide anions. This study aimed to investigate the effect of the SOD2 gene polymorphism (rs5746136) on SOD activity and biomarker levels in breast cancer patients. This study aimed to investigate the effect of SOD2 gene (rs5746136) polymorphisms on SOD activity and biomarkers levels in breast cancer patients. The spectrophotometry methods were used to detect malondialdehyde (MDA) and Catalase (CAT), Superoxide dismutase (SOD), and Glutathione (GSH) levels, which reflect antioxidant capacity, and the genotypes of rs5746136 were detected utilize PCR and RFLP. According to the current findings, the GA genotype of the control group was the most common (70%), followed by GG and AA genotypes (26.7% and 3.3%) respectively. In the patient group, the most common genotype was GG (45.6%), followed by the GA genotype (42.8%) and then the AA genotype (11.4%) The frequency of heterozygous genotype G/A compared to the homozygous genotype (G/G) [OR = 0.3571, 95% CI = 0.1375–0.9277, P = 0.0345]. The AA genotype is significantly associated with an increased risk of developing BC [OR = 2.00, p = 0.5403, CI: 0.2175–18.3883]. No significant differences were found in frequencies of the A allele between patients and control groups [OR = 0.7872, 95% CI = 0.4198–1.4762, P = 0.4558]. In addition, there are modest (P 0.05) relationships between serum biochemical parameters levels and rs5746136 genotype in breast cancer patients, but a substantial association between serum SOD activity and GSH concentration and GA and GG rs5746136 genotype in the control group. In conclusion, the current investigation suggests that the AA genotype of (rs5746136) in the MnSOD gene may be associated with an increased risk of breast cancer. The chosen SOD2 variants (rs5746136) play a crucial role in controlling the activity of the SOD enzyme.</p> </abstract>