Altogether these findings suggest that EG-VEGF/receptors system might be an important actor in the CRC progression into PC and might be involved in the ability of tumor cells to invade other organs. Circulating EG-VEGF could be proposed as a prognostic marker in human CRC and its progression into PC.

Les paragangliomes rétropéritonéaux non fonctionnels sont des tumeurs rares. Ils sont définis comme des tumeurs chromaffines extra- surrénaliennes et représentent environ 1/5ème des tumeurs chromaffines. Ils sont souvent asymptomatiques et peuvent atteindre des dimensions importantes. Nous rapportons l'observation d'une patiente âgée de 34 ans opérée pour une tumeur rétropéritonéale géante et dont l'examen anapath a conclu à un paragangliome. Les formes malignes, plus fréquentes que les formes bénignes, présentent un envahissement locorégional et métastasent tardivement. La prise en charge des paragangliomes doit être multidisciplinaire mais seul le traitement chirurgical est curatif. Il n'existe par contre pas de consensus sur l'utilité des thérapeutiques complémentaires qui peuvent néanmoins constituer un appoint à titre symptomatique. Les paragangliomes présentent un caractère génétique dans 25% des cas. Une enquête génétique doit être systématiquement proposée.

Les tumeurs stromales gastro-intestinales sont des tumeurs mésenchymateuses peu fréquentes dont la localisation rectale est extrêmement rare, et posent en pré-opératoire un problème de diagnostic et de prise en charge thérapeutique. Nous rapportons le cas d’une tumeur stromale à localisation rétro-rectale afin de bien étayer les particularités cliniques, radiologiques et thérapeutiques de cette entité rare.

Stromal tumors of the small bowel, commonly known as GIST (Gastrointestinal Stromal Tumors) are mesenchymal tumors of uncertain prognosis. They develop in the wall of the digestive tract. They are usually asymptomatic, incidentally discovered during endoscopy or during surgery. Identifying gastrointestinal stromal tumor is facilitated by a relatively specific marker, c-kit. Diagnosis is confirmed by histological examination of the surgical specimen. They pose two problems first is to confirm the diagnosis and second problem is to assess their evolutionary potential and customize the therapeutic management. We report the case of a patient aged 34 years with no history of prior illness. He was admitted a year ago in the emergency room in a state of hemorrhagic shock due to lower gastro intestinal (GI) bleeding for three days. The patient underwent conservative therapy with I.V fluids and blood transfusions. An endoscopic assessment consisting of upper and lower GI(UGIE and colonoscopy) was done but that did not reveal any abnormalities. Case StudySurgical exploration revealed a tumor 1 meter distal to the ligament of Treitz. Rest of the exploration was unremarkable. The tumor along with small bowel was resected and end anastomosis was performed. The postoperative course was uneventful. Histological study of the surgical specimen confirmed that this was a stromal tumor with low potential of malignancy. The staging did not reveal any secondary lesions. Stromal tum often asymptomatic, lower GI bleeding is an exceptional way of presentation. Complete resection of the tumor is the treatment of choice. The recent development of targeted therapies and molecular biology is a new hope in the treatment of these tumo review the diagnostic and therapeutic aspects of this disease, and explain that hemorrhagic shock can be due to jejunal stromal tumor