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Objective To evaluate the postoperative visual outcome and complications of 25‐gauge pars plana vitrectomy (PPV) via a lateral approach without proptosis of the globe in dogs. Procedures We reviewed the medical records of dogs diagnosed with giant rhegmatogenous retinal detachment (RRD) at Yokohama Animal Eye Clinic from 2016 to 2019 and treated by 25‐gauge PPV. Medical records included signalment, follow‐up time, etiology and duration of RRD, angle between the outermost trocar ports, immediate postoperative anatomic success rate, pre‐ and postoperative visual status, and postoperative complications. Results Seventy‐two dogs (78 eyes, 13 breeds) were included. The most common breed was the Toy Poodle (48.6%), and the mean follow‐up time was 690.6 days. The most common etiology of RRD was cataract surgery (46.2%). The mean angle between the outermost trocar ports was 71.4º. Immediate postoperative anatomic success was noted in all eyes. Vision was regained or maintained in 87.2% of eyes, and the mean time to return of vision was 28.5 days. Maintenance of vision until the last known follow‐up was noted in 73.5% of eyes. The most common postoperative complication was glaucoma (40.3%), and glaucoma was the most common etiology of postoperative vision loss (88.9%). Conclusion Twenty‐five gauge PPV via a lateral approach without proptosis of the globe is a successful method for treating canine giant RRD.

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