Background. The research results of fat-soluble vitamin D3 (cholecalciferol) encapsulation with β-cyclodextrin have been presented in this work. The vitamin D3 inclusion complex with β-cyclodextrin was obtained under microwave radiation. The surface morphology of obtained clathrate inclusion complexes was described with the help of a scanning electron microscope. The thermographic measurement results on a differential scanning calorimeter have been presented. The activation energy of the β-cyclodextrin : vitamin D3 clathrate complex thermal oxidative destruction reaction was calculated. The clathrate thermal destruction kinetic parameters were determined. The inclusion complex spectral properties were characterized by IR-Fourier and 1H and 13C NMR spectroscopy. The existence of β-cyclodextrin inclusion complex with vitamin D3 in a 2 : 1 ratio was confirmed by the experimental results. The activation energy of thermal destruction of the inclusion complex of β-cyclodextrin with vitamin D3 was calculated using four different methods.

Selective extraction of magnesium from asbestos-containing raw materials In this work, great attention was paid to identifying the reasons for the absence of practically implemented technologies for processing chrysotile asbestos wastes and searching for new methods for treating wastes with the aim of obtaining magnesium and other useful products of commercial interest. A series of experiments with solutions of ammonium chloride of different concentrations was carried out to study the kinetics of magnesium leaching. The concentration of magnesium leached increases with the concentration of the NH 4 Cl solution (C Mg = 0.092M; C Mg = 0.1M; C Mg = 0.102M), as well as with the time of the process itself. It was shown that the difference between the leaching rates of magnesium by 3M and 5M NH 4 Cl solutions was not significant, and it was rather large for 1M and 3M solutions. The study of the thermodynamics of magnesium leaching was carried out with 3 molar solution of ammonium chloride at various temperatures. Graphs of the concentration of leached magnesium versus the leaching time at different temperatures of the ammonium chloride solution were plotted based on the results obtained. Experiments showed that the degree of magnesium leaching from asbestos increased with increasing temperature. The activation energy was calculated, which was equal to 44 kJ. Sediment identification was carried out using a laser-atomic emission spectrometer apparatus. The results of the experiment showed that a certain amount of magnesium, calcium and a small amount of other metals were contained in the obtained precipitates. Admixture of calcium does not affect the properties of the precipitate obtained. Leaching tests carried out with the help of ammonium chloride solution of various concentrations showed that the fibrous structure of asbestos was not destroyed.

This review has been summarized the data on the synthesis of new hybrid derivatives based on alkaloid molecules. At the same time, there have been analyzed methods for obtaining hybrid structures containing fragments of natural compounds molecules in combination with other biologically active plant metabolites, as leading compounds for the development of new pharmacologically valuable agents, with the aim of creating new original drugs. The combination of pharmacophoric residues in one molecule, namely various aromatic and heterocyclic substituents in the nucleoside position of natural alkaloids, opens up new possibilities for both the subsequent chemical modification of the polyfunctional derivatives obtained and their new diverse biological activity. Effective methods of synthesis have been developed on the basis of directed transformations of these compounds (or their precursors). A wide range of pharmaco-logical properties of combined compounds of these series with a combination of low toxicity is promising. Considering that the preparation of combined derivatives based on alkaloid molecules has been insufficiently studied, the targeted synthesis of new com-pounds is of interest both in terms of new medicinespreparation and the development of new methods of organic synthesis, as well as the molecules stereochemistry determination of a new series of compounds.

The article presents results on the synthesis and investigation of the structural features of a number of 1,4-disubstituted 1H-1,2,3-triazole derivatives of the alkaloid lupinine. Lupinine modification reactions were carried out at the hydroxymethylene group in the C-1 position of the quinolysine backbone. It has been shown that (octahydro-2H-quinolysine-1-ylmethyl)methanesulfonate in high yield (93%) is formed by the interaction of lupinine with methanesulfonyl chloride in methylene chloride. Subsequent treatment of this compound with sodium azide in dimethylformamide on heating leads to the formation of 1-(azidomethyl)octahydro-2H-quinolysine in 61% yield. It has been found that the reaction of a new azide with terminal alkynes of various nature in the presence of aqueous СuSO4 and sodium ascorbate in dimethylformamide can form the corresponding 4-substituted (1S,9aR)-1-[(1,2,3-triazol-1-yl)methyl]octahydro-1H-quinolysines. New 1,2,3-triazole derivatives of lupinine containing various aryl substituents at the C-4 position of the triazole ring have been obtained. The high selectivity of the reaction is explained by the action mechanism of the Sharpless catalyst. The spatial structure of the molecules of lupinine methanesulfonate, 4-aryltriazolylmethyl-octahydro-quinolysines has been established by X-ray diffraction analysis. X-ray structural analysis data of new compounds have been deposited in the form of CIF files at the Cambridge Crystallographic Data Center.

No abstract