Ionic compounds have been of global interest since stepping into a mature field of research. The aim of this study was to synthesize novel and known ionic compounds via the N‐alkylation process and fully characterize them by elemental analysis and infrared (IR) and nuclear magnetic resonance (NMR) spectroscopy. Investigation of the influence of the alkyl chain length and the charge of the cation on the ecotoxicity of 11 new and known ionic compounds based on tolperisone, diphenhydramine and trimecaine was investigated with the use of luminescence inhibition assay. To give information about the ecotoxicity of these new ionic compounds, the acute toxicity dataset of each compound was determined using Aliivibrio fischeri bacteria as a biomodel. According to the obtained results, the studied compounds could be considered non‐harmful to Aliivibrio fischeri. A quantitative structure–activity relationship (QSAR) study was carried out with the aim of modelling the observed behaviour and providing a prediction basis for ecotoxicity towards Aliivibrio fischeri.

Synthesis of 3-chloro-N,N-diethyl-N-(2-(mesitylamino)-2-oxoethyl)propan-1-aminium iodide (1) was performed by via N-alkylation in conventional conditions and using microwave irradiation and ultrasound activation. The synthesized ionic compound was characterized using IR, 1H and 13C NMR, growth-stimulating activity had been tested for ten varieties and hybrids of sweet sorghum seeds.

The present work describes the synthesis, growth‐regulating activity, and antimicrobial behavior of ionic compounds based on 2‐diethylamino‐N‐(2,4,6‐trimethylphenyl)acetamide (trimecaine). Synthesis of ionic compounds was performed via N‐alkylation of trimecaine with alkyl halides using microwave and ultrasound activation and the results were compared with those of classical conditions (thermal activation). The synthesized ionic compounds have been tested for germination energy and capacity with the collection of different varieties and hybrids of sweet sorghum seeds. The valuable results were obtained for the seeds stored for several years for which the significant drop in germination activity is usually observed. Furthermore, the ionic compounds were used to study their biological activity – growth –regulating activity on sweet sorghum seeds and the antimicrobial behavior against E. coli, S. typhimurium, B. subtilis, S. aureus, P. aeruginosa, and C. albicans microorganisms.

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