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Background There are few studies investigating TGC-associated hepatotoxicity in ICU patients, and the pathogenesis of hepatotoxicity and identification of risk factors are limited. Objectives To analyze the influence of tigecycline (TGC) on liver function in adult patients in the Intensive Care Unit to identify potential risk factors for tigecycline-induced liver injury (TILI). Methods Patients receiving tigecycline treatment in ICU during January 2019 to October 2020 were retrospectively enrolled. The liver function parameters before and after tigecycline treatment were collected, and risk factors associated with TILI was identified by logistic regression analysis. The probability of 28-day mortality was determined in Cox regression analysis. Results A total of 242 patients were enrolled, and TILI was identified in 24 patients (9.92%), of whom 75.0% had grade 1 liver injury, and 16.67%, 4.17%, 4.17% had grade 2 to 4 liver injury, respectively. The pattern of hepatotoxicity was hepatocellular in 16 patients (66.67%), cholestatic in 4 patients (16.67%), and mixed in 4 patients (16.67%). The median time from tigecycline start to symptoms was only 5 days (IQR, 3-7 days). Multivariate analysis identified tigecycline dose ≥ 200mg/day, longer course of treatment and preexisting liver disease tend to be independently associated with TILI. In addition, APACHE II score > 15, higher dose of tigecycline and TILI were independent risk factors of 28-day mortality, while longer course of tigecycline reduced this risk despite its association with TILI. Conclusions The maintenance dose and course of tigecycline, as well as liver disease is considered as risk factors of hepatotoxicity. 28-day mortality tended to be higher in TILI patients. The relationships among tigecycline dose and course, TILI and mortality should be further investigated.

The incidence of coronary heart disease increases year by year with the material level of our country. It has a harmful effect on the patient’s life health and quality of life. Movement Instruction is an important aspect of the secondary prevention project of cardiac rehabilitation in patients with coronary heart disease. Although it has a history of decades at inland and abroad, the present situation in China is not optimistic. Some studies have shown that the popularization and participation of cardiac rehabilitation is true and lacking. This paper sums up the relevant knowledge of coronary heart disease, coronary heart disease movement instruction and its impact on community life of patients at home and abroad, and reviews the research results of movement instruction on community rehabilitation of coronary heart disease in recent years, which provides a theoretical reference and prospect for the future research of community exercise rehabilitation of coronary heart disease.