We have developed a high-efficiency and practical Cu-catalyzed cross-coupling to directly construct versatile α-aryl-esters by utilizing readily available aryl bromides (or chlorides) and malonates. These gram-scale approaches occur with turnovers of up to 1560 and are smoothly conducted by the usage of a low catalyst loading, a new available ligand, and a green solvent. A variety of functional groups are tolerated, and the application occurs with α-aryl-esters to access nonsteroidal anti-inflammatory drugs (NSAIDs) on the gram scale.

We have established a practical and concise method to straightforward access a universal deuterated methylthiolating reagent through a one-pot gram-scale operation under mild conditions. This odourless electrophilic SCD3 reagent is...

A new type of organocatalyzed 1,3-thiosulfonylation has been developed to straightforward access highly functionalized vinyl sulfones, which features mild conditions, atom and step economy, practicability, conciseness, and environmental friendliness. Moreover,...