Following a previous genome-wide association study (GWAS 1) including 744 cases and 895 controls, we analyzed genome-wide association data from a new cohort of Han Chinese (GWAS 2) with 1,510 polycystic ovary syndrome (PCOS) cases and 2,016 controls. We followed up significantly associated signals identified in the combined results of GWAS 1 and 2 in a total of 8,226 cases and 7,578 controls. In addition to confirming the three loci we previously reported, we identify eight new PCOS association signals at P < 5 × 10(-8): 9q22.32, 11q22.1, 12q13.2, 12q14.3, 16q12.1, 19p13.3, 20q13.2 and a second independent signal at 2p16.3 (the FSHR gene). These PCOS association signals show evidence of enrichment for candidate genes related to insulin signaling, sexual hormone function and type 2 diabetes (T2D). Other candidate genes were related to calcium signaling and endocytosis. Our findings provide new insight and direction for discovering the biological mechanisms of PCOS.
A whole systems analysis of current and future water used for energy is presented. The energy sector's compliance with the "3 Red Lines" water policies is assessed. Future energy plans could conflict with the "3 Red Lines" industrial water policy. Water used for energy is highly dependant on technology choices. Co-benefits and trade-offs between future energy and water plans are identified.
a b s t r a c tIncreasing population and economic growth continue to drive China's demand for energy and water resources. The interaction of these resources is particularly important in China, where water resources are unevenly distributed, with limited availability in coal-rich regions. The "3 Red Lines" water policies were introduced in 2011; one of their aims is to reduce industrial water use, of which the energy sector is a part. This paper analyses current water withdrawals and consumption for all energy processes and assesses the sector's compliance with the industrial water policy under different scenarios, considering potential future policy and technological changes. The results show that future energy plans could conflict with the industrial water policy, but the amount of water used in the energy sector is highly dependant on technology choices, especially for power plant cooling. High electricity demand in the future is expected to be met mainly by coal and nuclear power, and planned inland development of nuclear power presents a new source of freshwater demand. Taking a holistic view of energy and waterfor-energy enables the identification of co-benefits and trade-offs between energy and water policies that can facilitate the development of more compatible and sustainable energy and water plans.
As an effective substitute for bank credit to ease financing constraints, trade credit plays an important role in the operation and growth of enterprises. This paper extends the literature by providing evidence on the relationship between trade credit financing and firm-level sustainable growth. Using the financial statement data of 20,089 Chinese A-share listed firms over the period 2003 to 2017, running a regression using the cross-section regression method and employing the two-stage instrumental-variable regression method in the endogeneity test, the study finds that trade credit has an overall positive and significant impact on the sustainable growth of Chinese firms, especially for firms with higher internal control ability, trade credit financing contributes more to sustainable growth, and the same way with private enterprises, whose growth depends more on trade credit compared to state-owned firms. We further find that the link between trade credit financing and sustainable growth of a firm is stronger in areas with lower access to finance, suggesting that firms with higher dependence on trade credit financing exhibit higher rates of sustainable growth in areas with weaker financial institutions.
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