In this work, the low-cost hierarchically porous nitrogen-doped carbon nanosheets (PNCNs) were prepared via one-step carbonization and KOH activation process of grapefruit peels. The prepared PNCNs exhibit higher specific surface area due to the inducement of the KOH-assisted carbonization compared to directly carbonized grapefruit peels (DCGPs). The PNCNs exhibit excellent electrochemical performances with high specific capacitance up to 311 F g À1 , superior cycling stability over 10000 cycles with only 5.95 % capacitance degradation, high energy density of 17.7 W h kg À1 and power density of 1100 W kg À1 in 1 mol L À1 H 2 SO 4 electrolyte. All these electrochemical data are significantly better than the comparative DCGPs material. Moreover, the assembled symmetric supercapacitor in 1 mol L À1 Na 2 SO 4 aqueous electrolyte exhibits a high energy density of 34.05 W h kg À1 at a power density of 180 W kg À1 and retains 14.25 W h kg À1 even at 5400 W kg À1 .

As is well known, a gradual increase in capacity during cycling is a common phenomenon in previously reported oxide‐based anodes for lithium‐ion batteries. However, not only may this be superfluous for practical applications, but it may also imply the presence of some electrochemical instabilities and side reactions. To achieve ultrastable Li storage without such a gradual increase in capacity, the mechanism of this increase by using a MnO/graphene‐based nanohybrid (MnO@C/RGO) as an example was comprehensively explored. Then, the gradual increase behavior of the specific capacity was effectively restrained by rationally optimizing the cutoff voltage, which resulted in the MnO@C/RGO electrode maintaining a nearly constant capacity during cycling at different current densities. Taking the high current density of 2 A g−1 as an example, there was no clear capacity change (increase/attenuation) even over 2000 cycles with stable coulombic efficiencies of around 99.7 %. This ultrastable Li‐storage capability should mainly benefit from rational testing parameters and an optimal 3D conductive network. More importantly and interestingly, full cells were also assembled and tested by coupling MnO@C/RGO and commercial LiFePO4 as the anode and cathode materials, respectively. The full cells impressively exhibited superior rate performance and excellent cycling stability.

Abstract. The gametocyte-specific factor 1 (GTSF1) gene participates in DNA methylation and retrotransposon activation in germ cells, particularly during cell proliferation. The present study aimed to assess the level of GTSF1 gene expression in liver cancer tumor tissues, and its role in human hepatoma cell lines in vitro and in a nude mouse model in vivo. GTSF1 gene expression was detected in liver cancer tumor tissues, compared with in healthy controls, via reverse transcription quantitative polymerase chain reaction. An adeno-associated virus vector was used to study tumor stem cell proliferation in vivo. A plasmid expressing GTSF1 was constructed and transfected into various human hepatoma cell lines, in order to analyze the cellular proliferation and apoptosis of liver cancer cells using small interfering (si)RNAs in vitro. In the present study, GTSF1 gene expression was detected in 18/24 (75.0%) liver cancer tumor tissues from patients with hepatocellular carcinoma (HCC), and elevated GTSF1 expression was identified in the tissue of one of 32 healthy control samples (3.13%; P<0.05). Notably, the GTSF1 gene was expressed at a higher frequency in AFP-positive HCC samples (14/16, 87.50%) compared with in AFP-negative HCC samples (4/8, 50.0%; P=0.129). In addition, there was no statistical significance between GTSF1 expression in non-HBV-infected (71.42%) and HBV-infected HCC specimens (76.47%), as determined by a χ 2 test (P=0.921). It was demonstrated that GTSF1 significantly increased the tumorigenicity of Ad-shNC-transfected (GTSF1-positive) HepG2 cells in the nude mouse xenograft model, whereas the sizes and weights of the tumors in the GTSF1-negative group were dercreased in comparison with the GTSF1-positive group (P<0.05). Reduced levels of GTSF1 mRNA, along with fewer and smaller colonies, were identified in two groups of human liver cancer cells treated with with GTSF1-targeting siRNA, when compared with cells without GTSF1 mRNA interference (P<0.05). In summary, the present study elucidated the GTSF1 mRNA expression pattern in liver cancer, and investigated the potential role of GTSF1 in tumorigenesis. The data suggest an important role for the GTSF1 gene in the molecular etiology of hepatocarcinogenesis, and indicate a potential application of GTSF1 mRNA expression in liver cancer diagnosis and therapy.

Pleural mesothelioma (PM) with pericardial involvement is extremely rare. We now report a rare case of malignant PM with constrictive pericarditis as the first presentation. A 59-year-old male diagnosed with constrictive pericarditis underwent pericardiectomy and pericardial pathology revealed mesothelial hyperplasia. Eight months after surgery, the patient was admitted to the hospital with chest tightness and wheezing for 5 days. Computed tomography scan of the chest showed a left lung expansion insufficiency, limited bilateral pleural thickening, pericardial thickening with a small amount of pericardial effusion, and multiple enlarged lymph nodes in the mediastinum, bilateral supraclavicular fossa, bilateral cervical roots, and right axilla. The pleural malignancy should be possibly considered. Pathology after pleural puncture showed malignant PM. Pathology after left supraclavicular lymph node puncture biopsy showed metastatic malignant mesothelioma. The diagnosis of this patient was clear. Although malignant PM rarely involves the pericardial constriction, we cannot ignore the fact that malignant PM involves the pericardium. The patient has been diagnosed with constrictive pericarditis, accompanied by pleural thickening and pleural effusion. Without other pathogenic factors, pleural biopsy should be aggressively performed in patients with constrictive pericarditis to determine the cause. K E Y W O R D S constrictive pericarditis, malignant pleural mesothelioma, pericardium How to cite this article: He C-P, Tu D-W, Zhang T-W, et al. Malignant pleural mesothelioma with constrictive pericarditis as the first manifestation: A case report.

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