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Tuberculosis is a deadly communicable disease caused by the bacillus Mycobacterium tuberculosis (MTB), and pulmonary tuberculosis accounts for over 80% of the total cases. The 1,2,4-triazole is a privileged structure in the discovery of new drugs, and its derivatives act on various targets in MTB. In particular, 1,2,4-triazole hybrids can not only exert dual or multiple antitubercular mechanisms of action but also have the potential to enhance efficacy and reduce side effects. The present work aims to summarize the current status of 1,2,4-triazole hybrids as potential antitubercular agents, covering articles published between 2010 and 2020, to aid the further rational design of novel potential drug candidates endowed with higher efficacy, better compliance and fewer side effects.

In a technology-driven society, adolescents are particularly vulnerable to the effects of excessive screen time, and gender disparities are notable. However, evidence on the gender difference in excessive screen time among Chinese high school students is scarce. This study examined gender differences in excessive screen time and its impact on mental health and urinary incontinence among 15,055 high school-aged adolescents, including 7514 (49.9%) males and 7541 (50.1%) females with the mean age of 16.72 (SD 0.88) in Henan Province, China. A stratified two-stage cluster sampling design was applied. Mental Health Inventory of Middle School Students and International Consultation on Incontinence Questionnaire—Short Form was used to collect data about mental health and urinary incontinence status. The percentage of students reporting excessive screen time was 9.4%, predominantly male (15.3% versus 3.5%; p < 0.001). Physical disease, living on campus, and cigarette or alcohol consumption were common factors associated with excessive screen time in both genders. Students in their second or third year showed significantly lower rates of excessive screen time than their peers. In males, younger age, active sexual behavior, chronic constipation, and having a mother with a PhD degree were factors associated with a higher probability of reporting excessive screen time, while females living in a rural–urban continuum or whose mothers have a junior college degree were associated with higher odds of reporting excessive screen times. Excessive screen time was significantly positively correlated with mental health problems and urinary incontinence (p < 0.05). Results suggests the need to address excessive screen time and to focus separately on the mechanisms influencing excessive screen time in males and females.

Objective. This study was designed to explore the efficacy of azithromycin plus glucocorticoid adjuvant therapy on the levels of serum inflammatory factors and the incidence of adverse reactions in children with mycoplasma pneumonia. Method. A total of 90 eligible children with mycoplasma pneumonia in our hospital from January 2019 to January 2020 were recruited. They were assigned to receive either azithromycin (control group) or azithromycin plus glucocorticoid (experimental group) according to the order of admission. Outcome measures included clinical efficacy, serum inflammatory factor indicators, lung function, clinical symptom mitigation, length of hospital stay, immune function, incidence of adverse reactions, and psychological status of the eligible children. Results. Azithromycin plus glucocorticoid was associated with a significantly higher total clinical efficacy compared with azithromycin P < 0.05 . No significant differences were found in the serum inflammatory factor indices between the two groups P > 0.05 . The children given azithromycin plus glucocorticoid showed lower levels of serum inflammatory factors versus those given azithromycin alone P < 0.001 . Azithromycin plus glucocorticoid outperformed the monotherapy of azithromycin in terms of lung function P < 0.001 . Children after azithromycin plus glucocorticoid therapy had a faster clinical symptom disappearance and shorter length of hospital stay compared with after azithromycin alone P < 0.001 . Azithromycin plus glucocorticoid resulted in higher levels of immune function indices compared with azithromycin alone P < 0.001 . Azithromycin plus glucocorticoid was associated with a lower incidence of adverse reactions compared with azithromycin P < 0.05 . Lower Children’s Depression Inventory (CDI) scores were witnessed in children given azithromycin plus glucocorticoid compared with monotherapy of azithromycin P < 0.001 . Conclusion. Azithromycin plus glucocorticoid in children with mycoplasma pneumonia can effectively improve the clinical indicators of the children with promising efficacy and high safety, which is worthy of promotion and application.

INTRODUCTION: At present, the common telemedicine service quality evaluation methods can not obtain the key evaluation indicators, which leads to the low accuracy and low user satisfaction. OBJECTIVES: This paper constructs a telemedicine service quality evaluation model based on machine vision technology. METHODS: Machine vision technology is used to obtain telemedicine service information, preliminarily select service quality assessment indicators, complete the selection of indicators, build a telemedicine service quality assessment indicator system, adopt subjective and objective combination method to calculate the weight of service quality assessment indicators, and combine matter element analysis method to build a telemedicine service quality assessment model. RESULTS: The experimental results show that the Cronhach a is higher than 0.7, the Barthel index is higher than 90, and the satisfaction of many users is more than 90%. CONCLUSION: The proposed method solves the problems existing in the current method and lays a foundation for the development of telemedicine service technology.