ObjectiveTo explore the precise mechanism of electroacupuncture (EA) to delay cognitive impairment in Alzheimer disease.MethodsN-Acetylaspartate (NAA), glutamate (Glu) and myoinositol (mI) metabolism were measured by magnetic resonance spectroscopy, learning and memory of APP/PS1 mouse was evaluated by the Morris water maze test and the step-down avoidance test, neuron survival number and neuronal structure in the hippocampus were observed by Nissl staining, and BDNF and phosphorylated TrkB detected by Western blot.ResultsEA at DU20 acupuncture significantly improve learning and memory in behavioral tests, up-regulate NAA, Glu and mI metabolism, increase the surviving neurons in hippocampus, and promote the expression of BDNF and TrkB in the APP/PS1 transgenic mice.ConclusionThese findings suggested that EA is a potential therapeutic for ameliorate cognitive dysfunction, and it might be due to EA could improve NAA and Glu metabolism by upregulation of BDNF in APP/PS1 mice.

a promising and sustainable approach to tackle the challenges of the ever-increasing depletion of fossil fuels and environmental degradation. [1] The products of CO 2 electroreduction are diverse and include CH 4 , C 2 H 4 , CO, HCOOH, C 2 H 5 OH, and so on. Among them, formic acid has been known as a crucial industrial intermediate and ideal candidate for hydrogen storage and fuel cells, owning the highest net present value evaluated from a technoeconomic prospect. [2] Among the various potential catalysts, main group metal elements, including Sn, In, Sb, and Bi, exhibit notable selectivity and activity for electrocatalytic CO 2 -to-formate conversion. In particular, tin and its oxides attract much more attention as Formate catalysts because of their less toxic and environmentally benign properties. [3] Substantial research efforts have been devoted toward improving the performance of the CO 2 reduction reaction (CO 2 RR) by nanostructuring Sn and its derivatives. For example, nanostructured Sn-based catalysts, such as tin