Objective To evaluate the feasibility, safety, and efficacy of a new surgical method of U-shaped myometrial excavation and modified suture approach with uterus preservation for diffuse adenomyosis. Methods From January 2012 to December 2014, 198 patients with diffuse adenomyosis were surgically treated using this novel procedure in Zhengzhou Hua-Shan Hospital. Degree of dysmenorrhea, menstrual blood volume, serum CA 125, and uterine size before and at 1 month, 3 months, 6 months, 12 months, and 24 months after surgery were compared. Results Postoperatively, VAS score of dysmenorrhea, menstrual blood volume, serum CA 125 level, and uterine size significantly decreased at 1 month, 3 months, 6 months, 12 months, and 24 months from presurgical levels (all p < .001), but there were no differences at the follow-up time points. Two patients recurred at 18 months and 23 months after surgery, but both recovered after repeat surgery. Interestingly, 2 other patients recrudesced at 10 months and 12 months after surgery. In addition, only one patient was found to have a postoperative anaemia with fever, conservatively managed without surgery. Conclusion U-shaped myometrial excavation and modified suture approach with uterus preservation is a safe and feasible surgical approach to treat diffuse adenomyosis, with favourable outcomes.

In a light-probe vision measuring system, we first extract a rough contour of the marking points based on adaptive canny edge detection, in order to improve the extracting accuracy of the image co-ordinate of the marking points' centre. This paper shows that the edge of rough contour may be subpixel extracted with the method of the grey moment. This method can be extrapolated to any position in the image plane. Finally, the image co-ordinates of marking points' centre can be obtained with the weighted least-squares curve-fitting. In this paper, we extend the existing technique and provide a comprehensive evaluation of the proposed method. The results show that this method has higher stability precision than the exiting one. The extraction accuracy of this technique can achieve as low as 0.01 pixels. We have incorporated these ideas into the actual vision measurement of the Canny Elevator Co., Ltd.

Evaluating efficacy of probiotics combined with prebiotics in small intestinal bacterial overgrowth (SIBO) in subclinical hypothyroidism (SCH) in the second trimester. We collected data from 78 pregnant women with SCH (SCH group) and 74 normal pregnant women (control group) in second trimester, compare the differences in high sensitivity C-reactive protein (hsCRP), result of lactulose methane-hydrogen breath test and gastrointestinal symptoms assessed by GSRS scale between two groups. In SCH group, 32 patients with SIBO were selected as intervention group. Treatment with probiotics + prebiotics for 21 days; The differences of lipid metabolism, hsCRP, thyroid function level, methane-hydrogen breath test results and GSRS scores before and after treatment were compared to evaluate the therapeutic effect. (1) The positive rate of SIBO and methane, hsCRP levels in SCH group were higher than those in control group (P < 0.05), the total score of GSRS scale, mean score of indigestion syndrome, and constipation syndrome in SCH group were higher (P < 0.05). (2) The mean abundance of hydrogen and methane were higher in SCH group. (3) After treatment, serum levels of thyrotropin(TSH), total cholesterol(TC), triglyceride(TG), low-density lipoprotein (LDL), and hsCRP in intervention group were decreased, and high-density lipoprotein (HDL) was increased compared with before treatment (P < 0.05). (4) After treatment, methane positive rate, total score of GSRS scale, mean score of diarrhea syndrome, dyspepsia syndrome, and constipation syndrome were decreased (P < 0.05). (5) The average abundance of methane and hydrogen were lower. Probiotics combined with prebiotics are effective in the treatment of SIBO in pregnant SCH patients.Clinical Trial Registration Number: ChiCTR1900026326.

Objective: Evaluating efficacy of probiotics combined with prebiotics in small intestinal bacterial overgrowth (SIBO) in subclinical hypothyroidism (SCH) in the second trimester. Methods: We collected data from 78 pregnant women with SCH(SCH group)and 74 normal pregnant women(Control group) in second trimester，compare the differences in high sensitivity C-reactive protein (hsCRP), result of lactulose methane-hydrogen breath test and gastrointestinal symptoms assessed by GSRS scale between two groups.In SCH group, 32 patients with SIBO were selected as Intervention group. Treatment with probiotics + prebiotics for 21 days; The differences of lipid metabolism, hsCRP, thyroid function level, methane-hydrogen breath test results and GSRS scores before and after treatment were compared to evaluate the therapeutic effect. Results: 1. The positive rate of SIBO and methane，hsCRP levels in SCH group were higher than those in control group(P <0.05),the total score of GSRS scale, mean score of indigestion and constipation syndrome in SCH group were higher (P <0.05).2. The mean abundance of hydrogen and methane were higher in SCH group 3.After treatment, serum levels of thyrotropin (TSH), total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) and hsCRP in intervention group were decreased , and high-density lipoprotein (HDL) was increased compared with before treatment (P<0.05).4.After treatment, Methane positive rate, total score of GSRS scale, mean score of diarrhea syndrome, dyspepsia syndrome and constipation syndrome were decreased. (P < 0.05)5. The average abundance of methane and hydrogen were lower. Conclusion: Probiotics combined with prebiotics are effective in the treatment of SIBO in pregnant SCH patients . Clinical Trial Registration Number: ChiCTR1900026326