Stimulus-responsive carrier-free MTX–MAN conjugate nanoparticles could be expected to achieve dual-receptor-mediated self-recognizing, reduced drug dosage, and enhanced synergistic chemotherapeutic effects.

Herein, a novel and highly efficient strategy for the synthesis of dihydropyrazoles via Pd-catalyzed carboamination reaction of β,γ-unsaturated hydrazones with alkenyl and aryl halides is demonstrated. The present methodology provides...

This paper presents a 3D lidar SLAM system based on improved regionalized Gaussian process (GP) map reconstruction to provide both low-drift state estimation and mapping in real-time for robotics applications. We utilize spatial GP regression to model the environment. This tool enables us to recover surfaces including those in sparsely scanned areas and obtain uniform samples with uncertainty. Those properties facilitate robust data association and map updating in our scan-to-map registration scheme, especially when working with sparse range data. Compared with previous GP-SLAM, this work overcomes the prohibitive computational complexity of GP and redesigns the registration strategy to meet the accuracy requirements in 3D scenarios. For large-scale tasks, a twothread framework is employed to suppress the drift further. Aerial and ground-based experiments demonstrate that our method allows robust odometry and precise mapping in realtime. It also outperforms the state-of-the-art lidar SLAM systems in our tests with light-weight sensors.

Herein, we presented a novel and highly efficient strategy for the synthesis of dihydropyrazoles via Pd‐catalyzed carboamination reaction of alkenyl hydrazones with aryl triflates. The simultaneous formation of C−C and C−N bonds in one step is particularly appealing. This methodology provides a practical and efficient avenue of the synthesis of diversely aryl substituted dihydropyrazoles in good yields.