A nanoscale phase is known to coincide with colossal magnetoresistance (CMR) in manganites, but its volume fraction is believed to be too small to affect CMR. Here we provide scanning-electron-nanodiffraction images of nanoclusters as they form and evolve with temperature in La(1-x)Ca(x)MnO(3), x = 0.45. They are not doping inhomogeneities, and their structure is that of the bulk compound at x = 0.60, which at low temperatures is insulating. Their volume fraction peaks at the CMR critical temperature and is estimated to be 22% at finite magnetic fields. In view of the known dependence of the nanoscale phase on magnetic fields, such a volume fraction can make a significant contribution to the CMR peak.

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Novel thermosensitive liposomes with embedded Au nanoparticles (AuNPs) in the liposome bilayer were prepared by a combination method of film build and supercritical CO(2) incubation. These AuNPs-liposomes possess AuNPs that are embedded in the bilayer and a drug that is encapsulated in the central aqueous compartment. The AuNPs in the liposomes can strongly absorb light energy and efficiently convert the absorbed energy to heat. The localized heat induces a phase transition in the liposome bilayer and releases the drug. The drug release from the AuNPs-liposomes can be controlled by the irradiation time and AuNPs concentration in the AuNPs-liposomes at room temperature, where the AuNPs function as a nanoswitch for triggering drug release both spatially and temporally. The results suggest that drug release from the AuNPs-liposomes is due to a photothermic effect that induces phase transition of the liposomes rather than destruction of the liposome bilayer.

BackgroundWe aimed to evaluate the diagnostic performance of 99mTc-MIBI SPECT/CT and ultrasonography in patients with secondary hyperparathyroidism (SHPT), and explored the factors that affect the diagnostic performance.Methods 99mTc-MIBI SPECT/CT and ultrasonography were performed in 50 patients with SHPT within 1 month before they underwent surgery. Imaging results were confirmed by the pathology. Pearson correlation analysis was used to determine the correlation of PTH level with clinical data. The optimal cutoff value for predicting positive 99mTc-MIBI results was evaluated by ROC analysis in lesions diameter.ResultsForty-nine patients had a positive 99mTc-MIBI imaging results and 39 patients had positive ultrasonography results. The sensitivities of 99mTc-MIBI and ultrasonography were 98.00% and 78.00%, respectively. A total of 199 lesions were resected in 50 patients. Among them, 183 lesions were proved to be parathyroid hyperplasia. On per-lesion basis analysis, the sensitivity and specificity of 99mTc-MIBI and ultrasonography were 59.34% and 75.00% vs 46.24% and 80.00%, respectively. The Pearson correlation analysis showed that the serum AKP and PTH level had a significant linear association (r = 0.699, P < 0.001). The lesion diameter was a statistically significant predictive factor in predicting positive 99mTc-MIBI SPECT/CT. The optimal cutoff value for predicting positive 99mTc-MIBI results evaluated by ROC analysis in lesions diameter was 8.05 mm.ConclusionDual phase 99mTc-MIBI SPECT/CT imaging had a higher sensitivity in patients with SHPT than ultrasonography. Therefore, using 99mTc-MIBI positioning the lesion could be an effective method pre-surgical in patients with SHPT.