BackgroundHigh-grade prostatic intraepithelial neoplasia (HGPIN) is the precursor or premalignant form of prostate cancer. At least 30% patients with a confirmed HGPIN will develop prostate cancer within 1 year after repeated biopsy. HGPIN patients are the appropriate at-risk population for chemoprevention strategies investigation against prostate cancer. However the commonly used chemoprevention agents that targeted on hormonal imbalance or lifestyle-related factors showed varied results in HGPIN patients.MethodsLiterature searches were conducted in PubMed, EMBASE and Cochrane library according to Cochrane guidelines before January 31st, 2017. Direct meta-analysis were performed to summarize the efficacy of candidate chemopreventative agents Dutasteride, Flutamide, Toremifene, Selenium, Green tea components, Lycopene and natural food products combination. Adjusted indirect meta-analyses were employed to compare the relative efficacy of these candidate chemoprevention agents head-to-head.ResultsThe overall incidence of prostate cancer in HGPIN was slightly decreased by chemoprevention agents (25.7% vs 31.5%, RR = 0.92, 95% CI: 0.83-1.03, P = 0.183), with minor heterogeneity (I2 = 22.3%, χ2 = 15.08, P = 0.237), but without statistical significance. Subgroup analysis showed that green tea catechins significantly decreased prostate cancer in HGPIN patients (7.60% vs 23.1%, RR = 0.39, 95% CI: 0.16-10.97, P P = 0.044), with moderate heterogeneity (I2 = 47.9%, χ2 = 1.92, P = 0.166). The adjusted indirect meta-analysis favored green tea catechins over other chemoprevention agents, and significantly when compared to natural food products combination (RR = 0.355, 95% CI: 0.134-0.934).ConclusionThe overall efficacy of chemoprevention agents in HGPIN patients is limited. But Green tea catechins showed the superiority to decrease prostate cancer in HGPIN patients.

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Abstract. Artemisia apiacea (also known as Artemisia annua L) is a herb commonly used in traditional Chinese medicine. In the early 1970s, artemisinin was isolated and identified as the active antimalarial ingredient, and thereafter, A. apiacea and artemisinin have been studied extensively, such as anti-inflammation and antipyresis, antibacteria, antiparasitic and immunosuppression effects of A. apiacea extract. The present study investigated the extracts anti-allergic effect obtained from the dried flowering tips of A. apiacea in rats. A systemic anaphylactic reaction model was induced in rats using compound 48/80. Artemisia extract was administered 1 h prior to the injection of compound 48/80. Artemisia was extracted from dried flowering tips of A. deserti using 80% ethanol. Subsequently, the systemic anaphylactic shock, histamine release, scratching behavior and vascular permeability induced by compound 48/80 were evaluated. The administration of Artemisia extract at 200 and 400 mg/kg doses suppressed the systemic anaphylactic shock induced by compound 48/80 in a dose-dependent manner. Overall, the Artemisia extract was able to effectively decrease systemic anaphylactic shock, histamine release, scratching behavior and vascular permeability induced by compound 48/80 in a dose-dependent manner.

The leisure service function is an important component of the derivative function and non-market function of cultivated land. Therefore, exploring the strength of the cultivated land leisure service function with the help of spatial information technology is significant in guiding the proper utilization and protection of cultivated land resources. This paper constructed an evaluation system based on the three dimensions of ecological landscape, social activities, and economic performance, explored the spatial difference of the cultivated land leisure service function in Yuanyang County, the major grain-producing area along the Yellow River through spatial weighted overlay, classified the hot spots of leisure services and presented suggestions for improvement. Results show the following: (1) the landscape resources in the northern part are relatively monotonous, while those in the southern part are rich and evenly distributed. Spatial accessibility presents a distribution of “one core with multiple subcores”. The distribution of leisure service supply capacity is characterized by “multiple cores and multiple circles.” (2) The hot spots of the cultivated land leisure service function are the Urban Agricultural Central Area and the Ecological Agriculture Core Area in the middle of the county, and the Suburban Agritourism Development Area, the Yellow River Agritourism Transitional Area, and the Leisure Agriculture Connection Area on the periphery of the county. (3) The agricultural landscape should be fully protected and utilized in the Urban Agricultural Central Area. The spatial accessibility and regional reputation of the Ecological Agriculture Core Area need to be improved. The landscape diversity and landscape quality should be improved in the Suburban Agritourism Development Area. The Yellow River Agritourism Transitional Area needs to overcome the loss of tourists. The Leisure Agriculture Connection Area should increase the number of leisure and tourism facilities.

The prevailing offshore field development solutions, i.e., dry tree and wet tree systems, are confronted with serious technical and economic challenges in deep and ultra-deep waters resulting from the large depth of water, far offshore distance, and harsh ocean environmental conditions, as well as high cost. In response to these challenges, an innovative Deepwater Artificial Seabed (DAS) production system is proposed in this article. The DAS production system concentrates on well access and riser design, which enables shallow-water-rated subsea production systems to develop Deepwater (DW) and Ultra-Deepwater (UDW) fields. First, DW & UDW field development drivers are discussed and presented. This is followed by a detailed discussion of the merits and demerits of the prevailing dry tree and wet tree field development solutions. On this basis, the design philosophy and main characteristics of the DAS production system are presented and discussed in detail. Dynamic survival analysis for the fully coupled Floating Production Storage and Offloading (FPSO)-DAS production system is carried out. The artificial seabed stability is systematically investigated for both intact and damaged conditions. The global analysis results indicate that the DAS production system as developed experiences quasi-static responses even under extreme storm conditions, due to the location of the artificial seabed and the decoupling effects of the flexible jumpers. The new DAS production system is considered to be a competitive and cost-effective field development solution in depths of up to 3000 m.