Anti-allergic effect of Artemisia extract in rats

Abstract

Abstract. Artemisia apiacea (also known as Artemisia annua L) is a herb commonly used in traditional Chinese medicine. In the early 1970s, artemisinin was isolated and identified as the active antimalarial ingredient, and thereafter, A. apiacea and artemisinin have been studied extensively, such as anti-inflammation and antipyresis, antibacteria, antiparasitic and immunosuppression effects of A. apiacea extract. The present study investigated the extracts anti-allergic effect obtained from the dried flowering tips of A. apiacea in rats. A systemic anaphylactic reaction model was induced in rats using compound 48/80. Artemisia extract was administered 1 h prior to the injection of compound 48/80. Artemisia was extracted from dried flowering tips of A. deserti using 80% ethanol. Subsequently, the systemic anaphylactic shock, histamine release, scratching behavior and vascular permeability induced by compound 48/80 were evaluated. The administration of Artemisia extract at 200 and 400 mg/kg doses suppressed the systemic anaphylactic shock induced by compound 48/80 in a dose-dependent manner. Overall, the Artemisia extract was able to effectively decrease systemic anaphylactic shock, histamine release, scratching behavior and vascular permeability induced by compound 48/80 in a dose-dependent manner.

A Complementary Herbal Product for Controlling Giardiasis

“…A possible limitation of our study should be noted here.We used a high dose of A. annua ethanolic extract similar to a number of studies [ 96 , 97 ]. Using a high dose of A. annua ethanolic extract ensures sufficient concentration of all active ingredients, particularly polysaccharides, coumarins, saponins, phytosterols, essential oils, polyphenols, and flavonoids [ 98 ].…”

Carbopol emulgel loaded with ebastine for urticaria: development, characterization,in vitroandin vivoevaluation

“…The centrifugation test is vital for the determination of the stability of a topical formulation such as an emulgel and for the prediction of the shelf life of such a formulation. This test indicates the effect of physical stress on a semisolid preparation in terms of phase separation (Jadhav et al., 2010 ; Prakash et al., 2010 ; Deng et al., 2016 ; Islam et al., 2021 ). The prepared formulations of ebastine emulgels were passed through a physical test such as the freeze-and-thaw test and then centrifuged for stability.…”

“…The allergy was induced in the experimental animals according to the study of Deng et al. ( 2016 ) with some modifications. Histamine hydrochloride solution (0.1 µg/mL in a solution of water/glycerol 50/50, v/v) was injected with a diabetic insulin syringe into the upper layer of the dorsal skin for the induction of allergy.…”

Ethanolic Extracts of Artemisia apiacea Hance Improved Atopic Dermatitis-Like Skin Lesions In Vivo and Suppressed TNF-Alpha/IFN-Gamma–Induced Proinflammatory Chemokine Production In Vitro

“…Thereafter, the effects of A. apiacea and artemisinin such as their anti-inflammatory, antipyresis, antibacterial, and antiparasitic effects as well as the immunosuppressive effects of A. apiacea extracts have been extensively studied. Recently, an A. apiacea extract was found to be effective against systemic anaphylactic shock [ 14 ] and to have an anti-inflammatory effect on lipopolysaccharide-activated Raw264.7 macrophage cells [ 13 ]. However, the biological and pharmacological actions of Artemisia apiacea Hance in atopic dermatitis (AD) are not completely understood.…”