The development of the industrial revolution 4.0 era resulted in unlimited information technology media that are accessible to all people, especially teenagers who are currently studying. Activities that are using screen-based information technology media or Screen Based Activity (SBA), especially those that are not well controlled, can lead to physical disorders such as Computer Vision Syndrome (CVS). This study aims to determine the relationship between SBA and CVS complaints among Vocational High School Students. This research is a descriptive correlative study with a cross-sectional design. The sample consisted of 255 students majoring in information technology. The sample was selected using simple random sampling technique. SBA data collection was measured using the adolescent sedentary activity questionnaire, and the CVS complaints were measured using the CVS questionnaire. The results of the bivariate analysis test for the relationship between SBA and CVS complaints using the Spearman Rank test obtained a significant value of 0.000 (p ≤ 0.05) where there was a significant relationship between SBA and CVS complaints in students with a moderate correlation value of 0.416 and a positive correlation direction. This means that with the increasing duration of the SBA, the CVS complaints will increase in students at Vocational High School 1 Denpasar and vice versa. The writer recommends that educational institutions should pay attention to SBA in students by providing knowledge about controlled SBA to prevent CVS complaints. HIGHLIGHTS The continuous use of screen-based technology on students for daily activities can lead to physical disturbances The increase in complaints of CVS was found to be associated with the longer duration of SBA It is necessary to raise awareness and knowledge regarding health effect related to prolonged SBA and optimize the exposure time along with preventive measures in order to reduce CVS complaints among students GRAPHICAL ABSTRACT