a b s t r a c tMethanolic and acetonic extracts of apple pomace were evaluated for phenolic profiles, antioxidant properties and antiviral effect against herpes simplex virus type 1 (HSV-1) and 2 (HSV-2). Acetone extraction yielded the higher amounts of phenolic compounds. The extraction method influenced the phenolic composition although antioxidant activity correlated weakly with phenols concentration. Among the polyphenols analysed, quercetin glycosides were the most important family, followed by dihydrochalcones. Apple pomace extracts were able to inhibit both HSV-1 and HSV-2 replication in Vero cells by more than 50%, at non-cytotoxic concentrations. Selectivity indexes (SI) ranged from 9.5 to 12.2.

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Oleanolic, ursolic and 3β, 23-dihydroxyolean-12-en-28-oic acids, together with the new flavonoid, 3-acetoxy-7methoxyflavone (1), were isolated from the 60% aqueous ethanolic extract of the leaves and flowers of Salvia elegans with anxiolytic activity. The structure of 1 was established by combined spectral and chemical methods.