Dual-band terahertz metamaterial absorber with very sensitive sensing ability in terms of the surrounding index is demonstrated.

δ-Catenin binds the juxtamembrane domain of E-cadherin and is known to be overexpressed in some human tumors. However, the functions of δ-catenin in epithelial cells and carcinomas remain elusive. We found that prostate cancer cells overexpressing δ-catenin show an increase in multi-layer growth in culture. In these cells, δ-catenin colocalizes with E-cadherin at the plasma membrane, and the E-cadherin processing is noticeably elevated. E-Cadherin processing induced by δ-catenin is serum-dependent and requires MMP- and PS-1/γ-secretase-mediated activities. A deletion mutant of δ-catenin that deprives the ability of δ-catenin to bind E-cadherin or to recruit PS-1 to E-cadherin totally abolishes the δ-catenin-induced E-cadherin processing and the multilayer growth of the cells. In addition, prostate cancer cells overexpressing δ-catenin display an elevated total β-catenin level and increase nuclear distribution, resulting in the activation of β-catenin/LEF-1-mediated transcription and their downstream target genes as well as androgen receptor-mediated transcription. Indeed, human prostate tumor xenograft in nude mice, which is derived from cells overexpressing δ-catenin, shows increased β-catenin nuclear localization and more rapid growth rates. Moreover, the metastatic xenograft tumor weights positively correlate with the level of 29 kD E-cadherin fragment, and primary human prostate tumor tissues also show elevated levels of δ-catenin expression and the E-cadherin processing. Taken together, these results suggest that δ-catenin plays an important role in prostate cancer progression through inducing E-cadherin processing and thereby activating β-catenin-mediated oncogenic signals.

Various kinds of structure designs have been proposed to achieve the multiple-band metamaterial absorbers. However, the discrete distance of adjacent frequencies of multiple absorbers is considerably large, which will inevitably overlook a large amount of information hidden in the off-resonance absorption areas. Herein, a narrow discrete distance of dual-band terahertz absorber based on two pairs of an Au strip/dielectric layer backed by Au film is designed. Two nearly 100% absorptivities of resonance peaks having the discrete distance of only 0.30 THz are realized. The relative discrete distance of the device is 13.33%, and this value can be adjusted via the length change of an Au strip. Furthermore, we present two narrow discrete distances of a triple-band absorber through stacking one more pair of an Au strip and dielectric layer. Results prove that two discrete distances of only 0.14 THz and 0.17 THz in adjacent absorption modes of the first two and the last two are achieved, respectively; the relative discrete distances of them are respectively 6.57% and 7.22%, which are far from previous reports. Narrow discrete distances (or low values of relative discrete distance) of the multiple-band absorbers have a large number of applications in the investigation of some hidden information in very near frequencies.

Highlights d Expression of PDL1 is a predictor for response to immunotherapy in thymic carcinoma d Alterations of CYLD are exclusively found in tumor samples of the responders d Alterations of BAP1 are exclusively found in tumor samples of the non-responders

This paper presents a kind of multi-band terahertz superabsorber, its surface structure consists of a square metallic patch with a very small rectangular hole whose area is only 3.94% of...