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Recently, digital pathology is an essential application for clinical practice and medical research. Due to the lack of large annotated datasets, the deep transfer learning technique is often used to classify histopathology images. A softmax classifier is often used to perform classification tasks. Besides, a Support Vector Machine (SVM) classifier is also popularly employed, especially for binary classification problems. Accurately determining the category of the histopathology images is vital for the diagnosis of diseases. In this paper, the conventional softmax classifier and the SVM classifier-based transfer learning approach are evaluated to classify histopathology cancer images in a binary breast cancer dataset and a multiclass lung and colon cancer dataset. In order to achieve better classification accuracy, a methodology that attaches SVM classifier to the fully-connected (FC) layer of the softmax-based transfer learning model is proposed. The proposed architecture involves a first step training the newly added FC layer on the target dataset using the softmax-based model and a second step training the SVM classifier with the newly trained FC layer. Cross-validation is used to ensure no bias for the evaluation of the performance of the models. Experimental results reveal that the conventional SVM classifier-based model is the least accurate on either binary or multiclass cancer datasets. The conventional softmax-based model shows moderate classification accuracy, while the proposed synthetic architecture achieves the best classification accuracy.

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