Tetrahydropyranols. -The conversion of aldehydes with a range of aryl substituted secondary nitroallylic alcohols in the presence of a chiral prolinol derivative furnishes the title products with excellent stereoselectivities. The recovered, less reactive nitroallylic alcohol ((S)-Ia) can be further transformed via diastereoselective reduction of its double bond en route to enantioenriched 3-amino-2-hydroxy-phenylbutyric acids which are precursors of numerous biologically active skeletons including aminopeptidase and HIV-1 protease inhibitors. -(GURUBRAHAMAM, R.; CHENG, Y.-S.; CHEN*, K.; Org. Lett. 17 (2015) 3, 430-433, http://dx.
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