Statistical characteristics of pressure fluctuation on the casing wall of two axial flow compressor rotors have been investigated experimentally to find a precursor of rotating stall. Near stall, the casing wall pressure across a flow passage near the leading edge is characterized by a highly unsteady region where low-momentum fluid accumulates. The periodicity of the pressure fluctuation with blade spacing disappears and an alternative phenomenon comes into existence, which supports the disturbance propagating at a different speed from the rotor revolution. The precursor of rotating stall can be detected by monitoring collapse of the periodicity in the pressure fluctuation. To represent the periodicity qualitatively, a practical detection parameter has been proposed, which is easily obtained from signals of a single pressure sensor installed at an appropriate position on the casing wall during operation of a compressor.

No abstract

The pressure fluctuations on the casing wall of two axial flow compressor rotors with various tip clearances have been analyzed by the use of two kinds of correlation functions. The behavior of the pressure fluctuation varies depending on tip clearance and blade solidity. In the case of small tip clearance, the nature of disturbances becomes random as the flow rate is reduced to a stall condition. For moderate tip clearance, coherent-structured disturbances appear intermittently at low flow rate. They appear more frequently as the solidity is increased and the flow rate becomes lower. For large tip clearance, the coherent structured disturbances exist even at considerably higher flow rates. Corresponding to these features, there are peculiar patterns in the correlation designated as “phase-locked correlation functions.”

The three-dimensional mixing field induced by a novel wall-mounted cavity having a three-dimensional shape, which has been proposed in the other literature, is investigated in detail by solving the Reynolds-averaged Navier-Stokes (RANS) equations computationally. The results indicate that secondary flows are produced from the cavity and that the secondary flows act on the transverse jet such a way that it penetrates highly into the primary flow; i.e., the computational results demonstrates that the proposed cavity functions effectively as a device for enhancing supersonic mixing.

Development of chemotherapy has led to a high survival rate of cancer patients; however, the severe side effects of anticancer drugs, including organ hypoplasia, persist. To assume the side effect of anticancer drugs, we established a new ex vivo screening model and described a method for suppressing side effects. Cyclophosphamide (CPA) is a commonly used anticancer drug and causes severe side effects in developing organs with intensive proliferation, including the teeth and hair. Using the organ culture model, we found that treatment with CPA disturbed the growth of tooth germs by inducing DNA damage, apoptosis and suppressing cellular proliferation and differentiation. Furthermore, low temperature suppressed CPA-mediated inhibition of organ development. Our ex vivo and in vitro analysis revealed that low temperature impeded Rb phosphorylation and caused cell cycle arrest at the G1 phase during CPA treatment. This can prevent the CPA-mediated cell damage of DNA replication caused by the cross-linking reaction of CPA. Our findings suggest that the side effects of anticancer drugs on organ development can be avoided by maintaining the internal environment under low temperature.