BackgroundThe purpose of this work was to report on the performance of medial blepharosynechioplasty (MBSP), a newly devised technique for treating severe dry eye.MethodsIn this retrospective, nonrandomized clinical trial, three cases with severe dry eye (Sjögren’s syndrome) associated with repeated punctal plug loss were treated using MBSP to create a synechia between the upper and lower lid medial borders of the puncta to suppress the lacrimal pump.ResultsPostoperative follow-up showed improvement in the corneal condition in all three cases that persisted for 12–35 months. None of the patients had visual impairment.ConclusionMBSP is a promising treatment for severe dry eye and merits further study.