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The Reconfigurable Transfer Line Balancing Problem (RTLB) is considered in this paper. This problem is quite recent and motivated by the growing need of reconfigurability in the new industry 4.0 context. The problem consists into allocating a set of operations necessary to machine a single part to different workstations placed into a serial line. Each workstation can contain multiple machines operating in parallel and the tasks allocated to a workstation should be sequenced since sequence-dependent setup times between operations are needed to perform tool changes. Besides, precedence constraints, inclusion, exclusion and accessibility constraints between operations are considered. In this article we propose an efficient matheuristic of type BFSL (Balance First, Sequence Last). This method is a two-step heuristic with a constructive phase and an improvement phase. It contains several components from exact methods (linear programming, constraint generation and dynamic