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The imm"noregulatory effects of dietary a-tocopherol (Toc) and tocotrienols (T-3) on humoral and cell-mediated immunity and cytokine productions were examined in Brewn Norwtty rats. We found that the IgA and IgG productivity of spleen and mesenteric lymph node anN) lymphocytes was significantly enhanced in the rats fed on Toc or T-3, irrespectiye of collcanavalin A (Cen A) stim"lation of the lymphocytes. On the contrary, the IgE preductiyity ef lymphecytes from the rats fed oll Tec or T-3 was less without Con A stimulation, but was greater in the presence of Con A, especially in the T-3 group. Toc or T-3 feeding signMcantly decreased the proportion of CD4' T cells and the ratio of CD4'!CD8' in both spleen and MLN lymphocytes of the rats fed on Toc or T-3. The interferon-7 productiyity ef MI.N lymphocytes was higher in the rats fed oll Toc or T-3 than in those fed on a control diet in the presence of Con A, while that of spleell lymphocytes was lower in the rats fed on Toc or T-3. I] addition, T-3 feeding decreased the productivity of tumor necrosis factor-a of spleen lymphocytes, while it enhanced the productiyity of MLN lymphocytes. These results sugges"hat oral administration of Tec and T-3 affects the proliferation and function of spleen and MLN lymphocytes.

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