The aim of the study was to compare dental and periodontal status, oral hygiene, salivation rate, functional parameters of saliva and oral microbiota composition in patients with gastroesophageal reflux disease (GERD) with acidic and subacidic refluctant. The study comprised 69 participants divided in 3 groups: 22 healthy volunteers (controls) and 2 main groups: 25 GERD patients with acidic (group 2) and 22 patients with subacidic refluctant (group 3). Poor dental and periodontal condition was revealed in group 3 patients probably because of aggressive intestinal content reflux in the oral cavity resulting in higher PMA an saliva pH values, Escherichia coli species in oral microbiota and low buffer capacity of saliva. The results show that GERD may be suspected due to oral manifestations thus promoting it's prompt treatment.

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Our study revealed the correlations between parameters that reflect changes in the systemic regulation of physiological functions during abnormal occlusion accompanied by disturbances in postural control. Estimating the heart rate variability, studying the posture (by means of computer optical topography), and performing the tests for activity of the autonomic nervous system showed that a normal functional state is characterized by coordinated activity of the postural control apparatus, occlusion of dentition, and other physiological systems. By contrast, the predominance of sympathetic autonomic regulation and anomaly of occlusion in the form of distal occlusion are is accompanied by the certain postural disorders (scoliosis of the 1st - 2nd degree in the frontal plane). Orthodontic treatment was followed by a decrease in activity of the sympathetic nervous system for heart rate regulation, which illustrates an increase in the adaptability of cardiovascular functions. These data are promising for an improvement of instrumental procedures for functional diagnostics in physiology and dentistry.