Keywords: benzo[f]isoquinoline, benzo[f]coumarin, 3-bromoacetylcoumarin, enamines of the 3,3-dimethyl-1,2,3,4-tetrahydroisoquinoline series, 2-(3-coumarinyl)-5,5-dimethyl-5,6-dihydropyrrolo[2,1-a]-isoquinolines, Chichibabin reaction.The classical method for the construction of the pyrrolo[2,1-a]isoquinoline system is the Chichibabin reaction, which involves the reaction of 1-methylisoquinoline with α-halo ketones [1, 2]. The successful use not only of heteroaromatic compounds such as pyridines and their benzo analogs but also of cyclic enamine derivatives in this reaction is well known [2,3]. Here 3-bromoacetylcoumarins are also worthy of attention as α-halo ketones in so far as the formation of a system consisting of two independent heterocyclic fragmentspyrrolo[2,1-a]isoquinoline and coumarin -has been proposed in this case. Structures of such a type are practically unknown in the literature. The aim of the present work was to investigate the possibilities of annelation of the pyrrole ring depending on the structure of the initial reagents.The investigations showed that the reaction of the isoquinoline 1 with 3-bromoacetylcoumarin takes place readily with boiling in 2-propanol in the presence of Na 2 CO 3 , with the formation of compound 2. If compounds 3a,b are used as initial enamines the reaction products are compounds 4a,b. The corresponding bromoacetyl derivative of benzo[f]coumarin gives compound 5a in reaction with the enamine 1 and the amide 5b in reaction with the enamino amide 3b. In reaction with 3-bromoacetylcoumarin the benzo[f]isoquinoline derivative 6 forms the tetracyclic system 7. The obtained coumarin derivatives 2, 4, 5, and 7 (Table 1) are yellow crystalline substances.In the 1 H NMR spectra of the synthesized compounds (Table 2), in contrast to the spectra of the initial enamines, there are singlets for the pyrrole ring (6.28-7.12 ppm), the shift of which depends on the substituent at position 1 of the pyrrolo[2,1-a]isoquinoline system. All the spectra contain singlets for the HC= group of the coumarin ring (7.80-8.56 ppm) [4].

The article deals with issues related to the problem of vocational rehabilitation of disabled people. The competence of the Russian Federation in the fi eld of rehabilitation of disabled persons in the person of its Federal authorities and management, subjects of the Russian Federation and local self-government bodies is specifi ed. The content of such concepts as "services for professional rehabilitation of disabled people" in accordance with the state standard GOST R 53873-2010 Rehabilitation of disabled people is disclosed. Professional rehabilitation services for the disabled; "professional rehabilitation program" and "options for professional rehabilitation". Despite the fact that professional rehabilitation and adaptation in the workplace is an integral part of the state policy in the fi eld of social protection of persons with disabilities, there are many unresolved problems and diffi culties in this area.

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The article deals with the issues of legal regulation of ensuring accessibility of higher education for the disabled and people with disabilities. The relevance of obtaining agricultural education in the Russian Federation, which should be as close as possible to the main consumer — the rural population, is emphasized. The openness of agricultural education to the needs of rural residents will help reduce migration fl ows and preserve young people in rural areas. Attention is drawn to the fact that obtaining agricultural education is possible and accessible not only for people without disabilities, but also for people with disabilities. The advantage of providing higher agricultural education to this category of rural residents is that they are not aimed at migration, they live permanently and for a long time in a certain territory. The review of the current legal acts regulating the issues of accessibility and training in higher education organizations for persons with disabilities and persons with disabilities is presented. The article analyzes current trends in the legal fi eld of inclusive education. The article considers the concept and legal status of disabled people and students with disabilities, the concept of inclusive education and the requirement for its implementation at all levels, including higher education.