A study of interleukin-6 (IL-6), hepcidin-25 (GP-25) was conducted in 22 patients with breast cancer before neoadjuvant chemotherapy and in 27 healthy women in the control group. Significant expression of the GP-25 protein was revealed in breast cancer patients, compared to control. The rates were high both in patients with anemic sindrome (AS) and without it (p <0.01). Latent iron deficiency, AS, IDA and functional iron deficiency (FJ) were more often detected in patients with stage III disease. A significant difference in the parameters of GP-25 and IL-6 was noted, the indicators were higher in patients with stage III (p <0.01). No close correlation was found between IL-6, GP-25 and other acute-phase proteins (FR, CRP) at the initial stages of AS formation. On the contrary, a positive correlation was observed in patients with IDA and FJ between IL-6 and all acute-phase proteins (GP-25, FR, CRP). However, a small number of observations do not allow an unambiguous conclusion about the role of IL-6 and GP-25 expression in the development of AS in cancer patients with breast cancer and requires further study.

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Папуша Людмила Ивановна, канд. мед. наук, врач-онколог боксированного отделения гематологии/ онкологии НМИЦ детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева Минздрава России.

The applicability of the work is to identify the possibility of productivity increase of cows of the Simmental breed due to reproductive qualities. The aim of the work is to assess the influence of the first insemination age, service period and dry period on milk productivity of Simmental cows. The research is aimed at studying milk productivity of Simmental cows with different levels of reproductive qualities. The obtained data were statistically processed in Excel. Descriptive statistics methods were used. The object of the research were Simmental cows of “ Tasaliev D.M. “ farm of Kaliningrad region. As a result of the study, a relation was established between the age of the first successful insemination, the service period duration, the dry period duration and parameters of milk productivity. The age of the first successful insemination at 18-24 months has the most beneficial effect on subsequent milk productivity. A service period of 90-120 days has a positive effect on milk yield increase for 305 days of lactation, a longer service period negatively affects the mass fraction of milk fat. Prolonged service period results in a calf loss of 100 calves per year. With an increase of dry period duration, the mass fraction of milk fat increases, but milk yield decreases. The influence of reproductive qualities on mass fraction of milk protein is insignificant. According to the results of the studies, it can be considered that reproductive qualities, in combination with other factors, influence milk productivity of Simmental cows.