2-Alkylaminomethylene-19beta,28-epoxyolean-3-ones were obtained by interaction of 2-hydroxymethylene-19beta,28-epoxyolean-3-one with aliphatic amines. Some of the resulting substances exhibit immunotropic activity.

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A series of substituted 1-arylamino-3,4-dihydroisoquinolines have been synthesized using reactions of 1-methylthio-3,3-dimethyl-3,4-dihydroisoquinolines with substituted anilines and 2-aminothiazoles. The products were tested for analgesic and antiinflammatory activity.Substituted 1-aminoisoquinolines, which can be also considered heterocyclic amidines, exhibit various types of biological activity. Compounds of this class were reported to act as antihypertensive agents [1], antitumor drugs [2], thrombin inhibitors (active upon peroral administration) [3], and specific DOPA receptor agonists [4]. Previously, we reported on the synthesis of 1-arylamino-3,3-dimethyl-3,4dihydroisoquinolines [5] with a general structure isosteric to 4-arylaminoquinazolines known to be protein kinase inhibitors [6].In continuation of these investigations, we have synthesized a series of amidines containing halogen-substituted arylimino (IIb -IId) or thiazolylamino (IIg -IIi) groups at the first position of the heterocycle, studied their antiinflammatory and analgesic properties, and compared their biologi-533 0091-150X/05/3910-0533

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