2020) A comparison of reproductive outcomes of patients with adenomyosis and infertility treated with High-Intensity focused ultrasound and laparoscopic excision, International ABSTRACT Objective: The aim of this study was to compare the treatment effects of high-intensity focused ultrasound (HIFU) and laparoscopic excision (LE) in patients with adenomyosis and infertility. Materials and methods: A total of 93 patients with adenomyosis and infertility who were treated with HIFU (50 patients) or LE (43 patients) from January 2012 to January 2017 at the Third Xiangya Hospital of Central South University were retrospectively analyzed. Clinical characteristics including dysmenorrhea severity pain score, menorrhagia severity scores, reproductive outcomes, complications during pregnancy and delivery, adverse effects, surgical complications, and other clinical variables were compared between the HIFU and LE groups. Results: Of the total 93 patients with adenomyosis and infertility, 50 were treated with HIFU and 43 underwent LE. Both HIFU and LE treatments achieved significant relief of dysmenorrhea and menorrhagia. The total hospital stay was shorter in patients treated with HIFU than in those who underwent LE surgery. Neither HIFU nor LE treatment led to severe complications after treatment. Most importantly, patients treated with HIFU showed significantly higher pregnancy rates and natural conception rates than those who underwent LE surgery. Notably, in the HIFU treatment group, those with diffuse adenomyotic lesions had significantly lower postoperative pregnancy rates than those with focal adenomyosis. Conclusion: HIFU showed a safe and effective profile as a therapeutic management option for patients with adenomyosis. In comparison with LE, HIFU treatment achieved better postoperative reproductive outcomes. HIFU treatment should be encouraged and implemented in clinical practice. ARTICLE HISTORY

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Route planning satisfied multiple requests is an emerging branch in the route planning field and has attracted significant attention from the research community in recent years. The prevailing studies focus only on seeking a route by minimizing a single kind of Travel Cost, such as trip time or distance, among others. In reality, most users would like to choose an appropriate route, neither fastest nor shortest route. Usually, a user may have multiple requirements, and an appropriate route would satisfy all requirements requested by the user. In fact, planning an appropriate route could be formulated as a problem of Multi-weight Multi-destination Route Planning with Deadlines Constraints (MWMDRP-DC). In this article, we propose a framework, namely, MWMD-Router, which addresses the MWMDRP-DC problem comprehensively. To consider the travel costs with time-variation, we propose not only four novel dynamic graph miner to extract travel costs that reveal users’ requirements but also two new algorithms, namely, Basic MWMD Route Planning and Advanced MWMD Route Planning , to plan a route that satisfies deadline requirements and optimizes another criterion like travel cost with time-variation efficiently. To the best of our knowledge, this is the first work on route planning that considers handling multiple deadlines for multi-destination planning as well as optimizing multiple travel costs with time-variation simultaneously. Experimental results demonstrate that our proposed algorithms deliver excellent performance with respect to efficiency and effectiveness.

Improved device performance to enable high-linearity power applications has been discussed in this study. We have compared the La2O3/SiO2 AlGaN/GaN metal–oxide–semiconductor high-electron-mobility transistors (MOS-HEMTs) with other La2O3-based (La2O3/HfO2, La2O3/CeO2 and single La2O3) MOS-HEMTs. It was found that forming lanthanum silicate films can not only improve the dielectric quality but also can improve the device characteristics. The improved gate insulation, reliability, and linearity of the 8 nm La2O3/SiO2 MOS-HEMT were demonstrated.