The small cell carcinoma of the ovary is a rare tumor with the very modest prognosis. It usually occurs in young women and in two-thirds of cases is associated with hypercalcemia. The treatment combines surgery, chemotherapy, and radiotherapy. Case Presentation. We report a case of small cell carcinoma of the ovary hypercalcemic type in a young Russian woman of 33 years in whom the first manifestations were abdominal pain syndrome. A laparotomy was performed by radical surgery. There were performed 4 courses of chemotherapy, and then conventionally radical operation was executed. Histologically, the diagnosis was confirmed. There was performed palliative chemotherapy, the patient’s death occurred within 10 months after making of the diagnosis. Conclusion. Hypercalcemic type of ovarian cancer is a rare, aggressive tumor with a poor prognosis.

No abstract

At the mining laboratory of VNIINerud we are studying the mechanism of rock fracture by miler bits. We studied the interaction of one tooth of a roller bit 135 mm in diameter, with the surface of the rock using a test rig with tensometers to determine the breakage conditions over a wide range of loads on the tooth (up to 4380 kg) and tooth rolling rates (from 0.322 to 3.27 m/sec) [1].From our investigations of the breakage of carbonate rocks (limestones and dolomites of various degrees of hardnera) we confirmed the conclmiom in [2], cited in [3,4], that the rock is regularly broken in several sequential cycles if the tooth has a small contact surface; if the contact surface is large, the rocks usually break after one or two cycles.Became the contact surface area influences the character of rock breakage, it is of theoretical and practical interest to study the stress distribution in the rock in relation to the area of its contact with a single tooth of a miler bit.We used a drill test rig and the optical polarization method, preserving the kinematics of interaction of the full-scale wedge-shaped tooth (with an edge angle of 00" and a width of 2.3 cm) with the end surface of a plate of oprically-acrive trampamnt plastic, 200 x 300 x 23.3 mm in size. The angle between the axis of the tooth and the end of the model was varied, during the interaction, between 74 ~ (imertion of tooth) and 106" (withdrawal of tooth), The maximum compressive thrusts measured with the aid of a teraometer at the moment when the tooth was vertical were 700, 1010, 1320, and 1630 kg. The material of the model had the following mechanical characteristic*: fringe value o z'as = 60 kg/cm z, modulus of elasticity E = 2.5' 104 kg/mm 2, Poisson's ratio ~ = 03.The test rig was not fitted out for opticaI polarization measurement~ and the design of the percussion head did not permit us to me a polariscope with straight light path. We therefore used a side-viewing polariscope system. In this system, the plane of the model was parallel to the optic axes of the polarizer and analyzer, and the polarized beams were turned through 90" with respect to the model by means of mirrors set at 45 ~ to the axes of the polarizer Pcos Fig. I and analyzer. We used green monochromatic light We took photographs of the fringe patterns obtained at various stages of the interaction of the tooth with the model under various loads and with various angles of inclination From the theory [5] it is known that if an inclined force P is resolved into two, components, perpendicular and parallel to the rightangled edge of a plate of thickness t (Fig. 1), then the radial stresses o r and o~ arising from the action of these forces at any point in the model will be ~r=--2p cos(0--=) (1) ~t r ' -2P sin sin (0 --a) G r ~t r 'Kishinev Polytechnic Institute.

Цель исследования: Оценка эффективности режима TIP (паклитаксел, ифосфамид, цисплатин) у пациентов c диссеминированными герминогенными опухолями при неудовлетворительном снижении уровня маркеров после первого курса ХТ.Материалы и методы: В многоцентровое нерандомизированное исследование II фазы вошли пациенты из 4 центров Российской Федерации c диагнозом герминогенной несеминомной опухоли яичка или внегонадной природы, промежуточным или неблагоприятным прогнозом согласно классификации IGCCCG. Всем пациентам был проведен 1 курс химиотерапии (ХТ) по схеме ВЕР (блеомицин 30 мг в день 1, 3, 5, этопозид 100 мг / м 2 в дни 1-5, цисплатин 20 мг / м 2 в дни 1-5). Пациенты с неудовлетворительной скоростью снижения опухолевых маркеров к 18-21 дню получили 4 курса TIP (паклитаксел 120 мг / м 2 в дни 1-2, ифосфамид 1500 мг / м 2 в дни 2-5, цисплатин 25 мг / м 2 в дни 2-5 + Г-КСФ с 6 по 15 дни). При наличии резидуальной опухоли размером более 1 см и технической возможности ее удаления, выполнялось хирургическое лечение. Первичной конечной точкой являлась однолетняя выживаемость без прогрессирования.