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Introduction. Currently, the importance of various factors in the acute period of myocardial infarction (MI) for the risk stratification of unfavourable course ofpost-infarction period is continued to be studied. Purpose. We aimed to identify the factors, affecting the formation of adverse outcomes of in-hospital and long-term postinfarction period in patients with ST-elevated MI (STEMI) undergone radiopaque interventions (ROI). Material and methods. The study included 954 STEMI patients admitted to the Kemerovo Cardiology Dispensary in the period from 2008 to 2010. Diagnostic coronary angiography was performed in 725 (76%) patients, and 557 (76.8%) of cases undergone myocardial revascularization (isolated balloon angioplasty, angioplasty with stenting). Results. The in-hospital mortality in STEMI patients was associated with the age older than 60 years (OR 2.4 95% CI 1.4-3.9, p<0.001), decrease in left ventricular ejection fraction (LVEF) less than 40% on admission (OR 1.9 95% CI 1.1-2.9) and contrast-induced nephropathy (CIN) (OR 1.9 95% CI 1.0-3.5). The area under the ROC-curve was 0.744 (0.693-0.796; р<0.001). Fatal outcomes within a year after MI were associated with the decrease of glomerular filtration rate (GFR) less than 60 ml/min/1.73 m (OR 1.4 95% CI 1.0-2.0), LVEF less than 40% (OR 1.7 95% CI 1.1-2.7), development of CIN (OR 2.3 95% CI 1.3-4.1). The area under the ROC-curve was 0.707 (0.665-0.749, р<0.001). The risk offatal outcome within a three-year observation period was shown to increase 6.8-fold in the presence of acute heart failure (AHF) Killip > II on admission (OR 6.8 95% CI 2.1-21.8), 3.4-fold (OR 3.4 95% CI 1.1-11.0) in patients of the older age category (>60 years), 4.1-fold in development of CIN (OR 4.1 95% CI 1.1-14.3). The area under the ROC-curve was 0.744 (0.632-0.856, р=0.001). Conclusion. The independent risk factors of fatal outcome development within the in-hospital period in STEMI patients undergone ROI were: the age older than 60years, LVEF reduce less than 40% and the presence of CIN. Fatal outcomes within a year after MI were associated with GFR decrease less than 60 ml/min/1.73 m, LVEF less than 40% and CIN development, and within three years - AHF Killip class II and greater, age older than 60 years, as well as CIN after ROI.

Aim. Determination of the prognostic value of 1.5-anhydroglucitol (1.5-AG) for the development of cardiovascular events in patients with coronary heart disease (CHD) within a year after a planned percutaneous coronary intervention (PCI). Materials and methods. A prospective study was conducted in Federal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Disease among 149 patients admitted to planned PCI in the period from 2016 to 2017. Criteria for inclusion in the study: age up to 70 years, angina I-IV functional classes or post-infarction cardiosclerosis, the presence of indications for planned PCI. Exclusion criteria from the study: previous myocardial revascularization; prosthetic heart valves; decompensation of chronic heart failure, anemia of any degree; acute coronary syndrome in index hospitalization; exacerbation of somatic diseases. The results of the research were processed by Statistica Windows 6.0. Results. During the year after planned PCI, 39 (26.14%) cardiovascular events were registered in patients with CHD, of whom more than half of the cases (51.28%) were associated with the presence of indications for PCI of de novo. Lower levels of 1.5-AG were observed in the group of patients with cardiovascular events (p=0.000). When patients were divided according to median of the studied marker patients with a concentration of 1.5-AG less 20.96 μg/ml (before PCI) were more likely to have PCI after restenosis of the stent, compared with patients whose median concentration of this marker was higher (p=0.028). The logistic regression method revealed a significant direct relationship reflecting the prognostic value of lower concentration of 1.5-AG in relation to the development of cardiovascular events in patients regardless of the presence of carbohydrate metabolism disorders [OR 0.25 (0.10-0.62)]. Conclusion. According to the results of the study, the prognostic value of the concentration of 1.5-AG less 20.96 µg/ml was established in relation to the development of cardiovascular events in patients with CHD during the year after a planned PCI, regardless of the presence of carbohydrate metabolism disorders.