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This study is aimed at verifying the causal relationship of chronic circadian desynchronization and changes in body weight control. Eight male albino F344 rats aged between 12-15 wk were subjected to twice weekly 12-h shifts of the daily light-dark (LD) cycle for 13 wk (3 mo). Continuous circadian phase shifts consisting of intermittent phase delay and advance and reduced circadian amplitudes were consistently displayed in all five experimental rats implanted intraperitoneally with heart rate, body temperature, and activity transponders. The experimental rat maintained a greater body weight during LD shifts and even after 10 days of recovery than that of the age-matched control rat, which was maintained on a regular LD cycle. Body weight gain was greater in the first 2 mo of LD shifts in the experimental rat than in the control rat. Relative to the baseline, food intake and activity percentages were increased and reduced, respectively, for the experimental rats. Features of these results, such as increased body weight gain and food intake, and reduced activity, suggest a causal relationship of chronic circadian desynchronization and changes in body weight control in male albino F344 rats. shift work; circadian rhythm; reentrainment; energy regulation ACUTE PERTURBATIONS of the circadian rhythm structure like the transmeridian flights and the shifts of working schedules are related to the so-called "jet lag" and "shift lag" syndrome, respectively, both of which are characterized by feelings of malaise, fatigue, sleepiness, insomnia, digestive troubles, irritability, impaired mental agility, and performance efficiency (3). These symptoms often last for a short term, and they disappear after several days of stay at the local time for the jet lag and during the day shifts for the shift lag. Long-term disruptions of circadian rhythms, like chronic shift work, are associated with several medical diseases. Cardiovascular diseases, gastrointestinal disorders, and negative pregnancy outcomes have been reported to be more common in shift workers than in day workers in several epidemiological studies (12,24,25). The mechanisms that are responsible for the association between work shifts and each disease are unclear. In addition to circadian rhythm and sleep factors, however, behavioral changes and social disturbances are also considered to be involved in disease mechanisms (11, 12) and coping ability of shift workers (17).In most industrialized countries, cardiovascular diseases are the leading cause of death and disability. Bøggild and Knutsson (2) reviewed 17 studies and concluded that, compared with day workers, shift workers have a 40% increase in risk of cardiovascular disease. Conventional risk factors for cardiovascular disease are related mainly to metabolic syndrome, including obesity, elevated serum total and low-density lipoprotein (LDL) cholesterol, low high-density lipoprotein (HDL)-cholesterol, elevated triglycerides, and impaired glucose tolerance. Previous survey studies show that the current work shift sta...

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Purpose The purpose of this paper is to present the knowledge structure based on the articles published in Library Hi Tech. The research hotspots are expected to be revealed through the keyword co-occurrence and social network analysis. Design/methodology/approach Data sets based on publications from Library Hi Tech covering the time period from 2006 to 2017 were extracted from Web of Science and developed as testbeds for evaluation of the CiteSpace system. Highly cited keywords were analyzed by CiteSpace which supports visual exploration with knowledge discovery in bibliographic databases. Findings The findings suggested that the percentage of publications in the USA, Germany, China, and Canada are high. Further, the most popular keywords identified in Library Hi Tech were: “service,” “technology,” “digital library,” “university library,” and “academic library.” Finally, four research issues were identified based on the most-cited articles in Library Hi Tech. Originality/value While keyword plays an important role in scientific research, limited studies paid attention to the keyword analysis in librarian research. The contribution of this study is to systematically explore the knowledge structure constructed by the keywords in Library Hi Tech.

Introduction: Awareness of psoriasis-related comorbidities has been established in the current guidelines; however, evidence regarding the association of bone density or bone fragility with psoriatic disease remains inconclusive. Methods: We conducted a systematic review and meta-analysis to assess bone mineral density and the risk of osteoporosis and fractures in patients with psoriatic disease, including those with cutaneous psoriasis and psoriatic arthritis. We searched electronic databases for published observational studies. A meta-analysis was performed using the random-effect model. Pooled estimates and their confidence intervals (CIs) were calculated. Small-study effects were examined using the Doi plot and Luis Furuya–Kanamori index. Results: The analysis of the standardized mean difference in the absolute value of bone mineral density at different measuring sites (lumbar spine, femoral neck, and total hip) revealed no significant difference between patients with psoriatic disease and non-psoriatic controls. The pooled results of the adjusted odds ratios (ORs) demonstrated no increased risk of osteoporosis in patients with psoriatic disease. Notably, patients with psoriatic disease had a higher OR of developing bone fractures (adjusted OR: 1.09; 95% CI: 1.06 to 1.12; I2: 0%). Conclusion: Patients with psoriatic disease may be more likely to develop fractures compared with non-psoriatic controls. This higher risk for fracture may not necessarily be associated with lower bone mineral density nor a higher risk for osteoporosis.