Nanoparticle-based antibacterial agents have emerged as an interdisciplinary field involving medicine, material science, biology, and chemistry because of their size-dependent qualities, high surface-to-volume ratio, and unique physiochemical properties. Some of them have shown great promise for their application in plant protection and nutrition. Here, GO-AgNPs nanocomposite was fabricated through interfacial electrostatic self-assembly and its antifungal activity against phytopathogen Fusarium graminearum was investigated in vitro and in vivo for the first time. The results demonstrated that the GO-AgNPs nanocomposite showed almost a 3- and 7-fold increase of inhibition efficiency over pure AgNPs and GO suspension, respectively. The spore germination inhibition was stimulated by a relatively low concentration of 4.68 μg/mL (minimum inhibition concentration (MIC)). The spores and hyphae were damaged, which might be caused by an antibacterial mechanism from the remarkable synergistic effect of GO-AgNPs, inducing physical injury and chemical reactive oxygen species generation. More importantly, the chemical reduction of GO mediated by fungal spores was possibly contributed to the high antimicrobial activity of GO-AgNPs. Furthermore, the GO-AgNPs nanocomposite showed a significant effect in controlling the leaf spot disease infected by F. graminearum in the detached leaf experiment. All the results from this research suggest that the GO-AgNPs nanocomposite developed in this work has the potential as a promising material for the development of novel antimicrobial agents against pathogenic fungi or bacteria.
(3+1)D topological phases of matter can host a broad class of non-trivial topological defects of codimension-1, 2, and 3, of which the well-known point charges and flux loops are special cases. The complete algebraic structure of these defects defines a higher category, and can be viewed as an emergent higher symmetry. This plays a crucial role both in the classification of phases of matter and the possible fault-tolerant logical operations in topological quantum error-correcting codes. In this paper, we study several examples of such higher codimension defects from distinct perspectives. We mainly study a class of invertible codimension-2 topological defects, which we refer to as twist strings. We provide a number of general constructions for twist strings, in terms of gauging lower dimensional invertible phases, layer constructions, and condensation defects. We study some special examples in the context of \mathbb{Z}_2ℤ2 gauge theory with fermionic charges, in \mathbb{Z}_2 \times \mathbb{Z}_2ℤ2×ℤ2 gauge theory with bosonic charges, and also in non-Abelian discrete gauge theories based on dihedral (D_nDn) and alternating (A_6A6) groups. The intersection between twist strings and Abelian flux loops sources Abelian point charges, which defines an H^4H4 cohomology class that characterizes part of an underlying 3-group symmetry of the topological order. The equations involving background gauge fields for the 3-group symmetry have been explicitly written down for various cases. We also study examples of twist strings interacting with non-Abelian flux loops (defining part of a non-invertible higher symmetry), examples of non-invertible codimension-2 defects, and examples of the interplay of codimension-2 defects with codimension-1 defects. We also find an example of geometric, not fully topological, twist strings in (3+1)D A_6A6 gauge theory.
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