Ten novel pleuromutilin derivatives with quinazolinone and thioether groups in the C 14 side chain have been designed and synthesised. The antibacterial activities of the target compounds were tested via the agar-well diffusion method in vitro in the concentration of 5.0 µg mL −1 The results showed that all target compounds had displayed obvious antibacterial activity against Staphylococcus aureus ATCC26112 and Staphylococcus aureus SC.

Eight novel ethyl 7-alkyl-6-(2-aryloxyethoxy)-4-hydroxyquinoline-3-carboxylates were synthesised and their structures were identifi ed by 1 H NMR, MS, and IR spectra. The anticoccidial activities of these compounds were evaluated according to the ACI (the anticoccidial index) method. The results showed that two of these compounds exhibited anticoccidial activities against Eimeria tenella in the chicken' diet with a dose of 27 mg kg -1 .

Synthesis and Antibacterial Activities of Pleuromutilin Derivatives with Quinazolinone and Thioether Groups. -Ten novel pleuromutilin derivatives (V) are synthesized, which all exhibit higher antibacterial activity against S. aureus strains than pleuromutilin. -(YAO, Y.-P.; DAI, F.-Y.; DONG, K.-K.; MAO, Q.; WANG*, Y.-L.; CHEN, T.; J. Chem. Res. 35 (2011) 1, 4-7, http://dx.doi.org/10.3184/174751911x556675 ; Dep. Chem., Sichuan Univ., Chengdu 610064, Sichuan, Peop. Rep. China; Eng.) -K. Wilckens 23-197

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