Precise microscale patterning is a prerequisite to incorporate the emerging colloidal metal halide perovskite nanocrystals into advanced, integrated optoelectronic platforms for widespread technological applications. Current patterning methods suffer from some combination of limitations in patterning quality, versatility, and compatibility with the workflows of device fabrication. This work introduces the direct optical patterning of perovskite nanocrystals with ligand cross-linkers or DOPPLCER. The underlying, nonspecific cross-linking chemistry involved in DOPPLCER supports high-resolution, multicolored patterning of a broad scope of perovskite nanocrystals with their native ligands. Patterned nanocrystal films show photoluminescence (after postpatterning surface treatment), electroluminescence, and photoconductivity on par with those of conventional nonpatterned films. Prototype, pixelated light-emitting diodes show peak external quantum efficiency of 6.8% and luminance over 20,000 cd m −2 . Both are among the highest for patterned perovskite nanocrystal devices. These results create new possibilities in the system-level integration of perovskite nanomaterials and advance their applications in various optoelectronic and photonic platforms.

Surface chemistry mediated direct optical patterning represents an emerging strategy for incorporating colloidal nanocrystals (NCs) in integrated optoelectronic platforms including displays and image sensors. However, the role of photochemistry of crosslinkers and other photoactive species in patterning remains elusive. Here we show the design of nitrene‐ and carbene‐based photocrosslinkers can strongly affect the patterning capabilities and photophysical properties of NCs, especially quantum dots (QDs). Their role beyond physical linkers stems from structure‐dictated electronic configuration, energy alignment and associated reaction kinetics and thermodynamics. Patterned QD layers with designed carbene‐based crosslinkers fully preserve their photoluminescent and electroluminescent properties. Patterned light emitting diodes (QLEDs) show a maximum external quantum efficiency of ≈12 % and lifetime over 4800 h, among the highest for reported patterned QLEDs. These results would guide the rational design of photoactive species in NC patterning and create new possibilities in the monolithic integration of NCs in high‐performance device platforms.

Proteolysis targeting chimera (PROTAC) is an emerging protein degradation strategy, which shows excellent advantages in targeting those so-called “undruggable” proteins. However, the potential systemic toxicity of PROTACs caused by undesired off-tissue protein degradation may limit the application of PROTACs in clinical practice. Here we reported a radiotherapy-triggered PROTAC prodrug (RT-PROTAC) activation strategy to precisely and spatiotemporally control protein degradation through X-ray radiation. We demonstrated this concept by incorporating an X-ray inducible phenyl azide-cage to a bromodomain (BRD)-targeting PROTAC to form the first RT-PROTAC. The RT-PROTAC prodrug exhibits little activity but can be activated by X-ray radiation in vitro and in vivo. Activated RT-PROTAC degrades BRD4 and BRD2 with a comparable effect to the PROTAC degrader and shows a synergistic antitumor potency with radiotherapy in the MCF-7 xenograft model. Our work provides an alternative strategy to spatiotemporally control protein degradation in vivo and points to an avenue for reducing the undesired systemic toxicity of PROTACs.

Raewyn Connell’s theoretical concept of hegemonic masculinity has been profoundly influential in feminist sociology. Despite the rich literature inspired by her theory, conceptual ambiguities have compromised its full potential. In this article, I critique a pessimistic tendency in the interpretation and application of hegemonic masculinity, which focuses on its regressive role in reproducing/legitimating heteronormative patriarchy while overlooking its progressive potential. I propose that revisiting Antonio Gramsci’s theorization of hegemony can help us understand hegemonic masculinity by its mechanism of domination—force accompanied by consent—rather than via certain pregiven masculine qualities. This reformulation of hegemonic masculinity not only pushes us to maintain a relational understanding of masculinities in empirical research, but also brings attention to Connell’s vision for social change.

Identity formation for asexual people can be complicated by limited societal awareness of asexualities. Consequently, people who eventually identify on the asexuality spectrum often adopt other sexual identities in their early lives. In this paper, we extend sexual identity development theory by analyzing the identity trajectories of asexual-spectrum people who once identified as bisexual or pansexual. Quantitative data suggests that about half of asexual-spectrum respondents once identified as bisexual or pansexual and a third closely associate with bisexual or pansexual terminology. Qualitative data supports these findings, revealing that bisexuality, pansexuality, and asexuality are not always seen as mutually exclusive categories by asexual individuals. We argue that the intelligibility of bi-/pansexuality positions them as identity pathways for many asexual-spectrum individuals who experience equal (albeit little to no) attraction toward people of any gender.