Multiple types of liver diseases, particularly cholestatic liver diseases (CSLDs) and biliary diseases, can disturb bile acid (BA) secretion; however, BA accumulation is currently seen as an important incentive of various types of liver diseases’ progression. Da-Chai-Hu decoction (DCHD) has long been used for treating cholestatic liver diseases; however, the exact mechanisms remain unclear. Currently, our study indicates that the liver damage and cholestasis status of the α-naphthylisothiocyanate (ANIT)-induced intrahepatic cholestasis and bile duct ligation (BDL)-induced extrahepatic cholestasis, following DCHD treatment, were improved; the changes of BA metabolism post-DCHD treatment were investigated by targeted metabolomics profiling by UPLC-MS/MS. DCHD treatment severely downregulated serum biochemical levels and relieved inflammation and the corresponding pathological changes including necrosis, inflammatory infiltration, ductular proliferation, and periductal fibrosis in liver tissue. The experimental results suggested that DCHD treatment altered the size, composition, and distribution of the BAs pool, led the BAs pool of the serum and liver to sharply shrink, especially TCA and TMCA, and enhanced BA secretion into the gallbladder and the excretion of BAs by the urinary and fecal pathway; the levels of BAs synthesized by the alternative pathway were increased in the liver, and the conjugation of BAs and the pathway of BA synthesis were actually affected. In conclusion, DCHD ameliorated ANIT- and BDL-induced cholestatic liver injury by reversing the disorder of BAs profile.

Floods are among the most expensive natural hazards experienced in many places of the world and can result in heavy losses of life and economic damages. The objective of this study is to analyze flood inundation in ungauged basins by performing near-real-time detection with flood extent and depth based on multi-source remote sensing data. Via spatial distribution analysis of flood extent and depth in a time series, the inundation condition and the characteristics of flood disaster can be reflected. The results show that the multi-source remote sensing data can make up the lack of hydrological data in ungauged basins, which is helpful to reconstruct hydrological sequence; the combination of MODIS (moderate-resolution imaging spectroradiometer) surface reflectance productions and the DFO (Dartmouth Flood Observatory) flood database can achieve the macro-dynamic monitoring of the flood inundation in ungauged basins, and then the differential technique of high-resolution optical and microwave images before and after floods can be used to calculate flood extent to reflect spatial changes of inundation; the monitoring algorithm for the flood depth combining RS and GIS is simple and easy and can quickly calculate the depth with a known flood extent that is obtained from remote sensing images in ungauged basins. Relevant results can provide effective help for the disaster relief work performed by government departments.

No abstract

The climatic characteristics and temperature profiles of freezing rain in China are analyzed based on the observational data at 650 stations in China from 2000 to 2015. The freezing rain of China is generally in stripe-shape spatial distribution. The stations with freezing rain over 100 station-hours are mainly concentrated at the southeast areas of Southwest China and high-elevation mountainous areas of Eastern China. There are mainly two types of freezing rain temperature profiles, including single-warmlayer profile and double-warm-layer profile. The freezing rain profiles of mountainous area and urban area in Southwest China are similar to each other, and the freezing rain in Central and East China shares the similar single-warm-layer profile. The profiles in South China show the characteristics of freezing rain's profile in both Southwest China and Central/East China as the position of stations. PA of freezing rain's profiles is negatively correlated with NA, with correlation coefficients ranging from −0.36 to −0.70. The configuration of weak cold/warm layer (both smaller than 150 ∘ C⋅hPa) is one of major reasons causing frequent freezing rain at mountainous areas of Southwest China. The more obvious the change of NA with the variations of PA is, the more the freezing rain is likely to occur.

Abstract:Both the similar and different effects of freezing drizzle, sleet and snow on microphysical properties of supercooled fog were analyzed for fourteen events during a comprehensive wire icing, fog, and precipitation observation experiment conducted at Enshi radar station (30 • 17 N, 109 • 16 E; 1722 m a.s.l.) on a hilltop in Shibanling, Hubei, China. Liquid precipitation is in a relatively stable form in mountainous areas. Short-term precipitation (1-3 h) is dominant with temperature below 0 • C. The wet scavenging effect of freezing drizzle on small fog droplets with a size range less than 6-12 µm is weak but is stronger for fog droplets with a larger size, which is opposite to the effects of solid precipitation, broadening the fog droplet spectra significantly. As the fog droplet diameter increases, the distributions of droplet spectra change from leptokurtosis to platykurtosis and from positive skewness to negative skewness. Occurrence of freezing drizzle would improve the positive correlation of N-r in dissipation and oscillation periods, resulting in the N-r relationship having a weak negative correlation in the maturity period, and resulting in the transition of the N-L and N-r relationships into positive correlations in the development period. Meanwhile, the emergence of solid precipitation particles would result in negative values for the correlation coefficients of N-L and N-r. The change in relationships among the microphysical properties was caused by the occurrence of different phase precipitation, showing the influence on the main microphysical mechanisms of supercooled fog.