Joint extraction of entities and relations is an important task in information extraction. To tackle this problem, we firstly propose a novel tagging scheme that can convert the joint extraction task to a tagging problem. Then, based on our tagging scheme, we study different end-toend models to extract entities and their relations directly, without identifying entities and relations separately. We conduct experiments on a public dataset produced by distant supervision method and the experimental results show that the tagging based methods are better than most of the existing pipelined and joint learning methods. What's more, the end-to-end model proposed in this paper, achieves the best results on the public dataset.

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Motivation Synthetic lethality (SL) is a promising form of gene interaction for cancer therapy, as it is able to identify specific genes to target at cancer cells without disrupting normal cells. As high-throughput wet-lab settings are often costly and face various challenges, computational approaches have become a practical complement. In particular, predicting SLs can be formulated as a link prediction task on a graph of interacting genes. Although matrix factorization techniques have been widely adopted in link prediction, they focus on mapping genes to latent representations in isolation, without aggregating information from neighboring genes. Graph convolutional networks (GCN) can capture such neighborhood dependency in a graph. However, it is still challenging to apply GCN for SL prediction as SL interactions are extremely sparse, which is more likely to cause overfitting. Results In this paper, we propose a novel Dual-Dropout GCN (DDGCN) for learning more robust gene representations for SL prediction. We employ both coarse-grained node dropout and fine-grained edge dropout to address the issue that standard dropout in vanilla GCN is often inadequate in reducing overfitting on sparse graphs. In particular, coarse-grained node dropout can efficiently and systematically enforce dropout at the node (gene) level, while fine-grained edge dropout can further fine-tune the dropout at the interaction (edge) level. We further present a theoretical framework to justify our model architecture. Finally, we conduct extensive experiments on human SL datasets and the results demonstrate the superior performance of our model in comparison with state-of-the-art methods. Availability DDGCN is implemented in python 3.7, open-source and freely available at https://github.com/CXX1113/Dual-DropoutGCN

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